吡咯咪唑
中文名称 | 吡咯咪唑 |
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中文同义词 | 1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑;吡咯咪唑盐酸盐;吡咯咪唑 |
英文名称 | Clemizole |
英文同义词 | 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole (Clemizole);1-(4-Chlorobenzyl)-2-(pyrrolizinomethyl)-1H-benzimidazole;1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole;Histacur;1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)benzimidazole;1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole;1-(4-CHLOROBENZYL)-2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZO[D]IMIDAZOLE HYDROCHLORIDE |
CAS号 | 442-52-4 |
分子式 | C19H20ClN3 |
分子量 | 325.84 |
EINECS号 | 207-133-5 |
相关类别 | 小分子抑制剂,天然产物;微生物Microbiology;小分子抑制剂;原料药;Inhibitors;API intermediates |
Mol文件 | 442-52-4.mol |
结构式 |
吡咯咪唑 性质
熔点 | 239-241℃ |
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沸点 | 506.1±40.0 °C(Predicted) |
密度 | 1.25±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 不溶于水; DMSO 中≥16.2 mg/mL;乙醇中≥95.8 mg/mL |
形态 | 固体 |
酸度系数(pKa) | 9.08±0.20(Predicted) |
Target | Value |
H1 receptor
() | |
TRPC5
() |
Clemizole hydrochloride is found to inhibit HCV RNA replication in cell culture that is mediated by its suppression of NS4B’s RNA binding, with little toxicity for the host cell. The EC 50 of Clemizole on the W55R mutant J6/JFH RNA is ~18 µM (2.25 times the EC 50 of the wild-type RNA). Clemizole is a novel inhibitor of TRPC5 channels. Clemizole efficiently blocks TRPC5 currents and Ca 2+ entry in the low micromolar range (IC 50 =1.0-1.3 µM). Clemizole exhibits a six-fold selectivity for TRPC5 over TRPC4β (IC 50 =6.4 µM), the closest structural relative of TRPC5, and an almost 10-fold selectivity over TRPC3 (IC 50 =9.1 µM) and TRPC6 (IC 50 =11.3 µM). Clemizole hydrochloride as a novel blocker of TRPC5 with a half-maximal inhibitory concentration of 1.1 µM. The concentration-response curves confirmed a concentration-dependent block of TRPC5 by Clemizole and revealed an apparent IC 50 of 1.1±0.04 µM.
Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice.