酚嘧啶 扑蛲灵
| 中文名称 | 酚嘧啶 扑蛲灵 |
|---|---|
| 中文同义词 | 含 4,4′-亚甲基双(3-羟基-2-萘甲酸) 的 1-甲基-2-(3-羟基苯乙烯基)-1,4,5,6-四氢嘧啶化合物;酚嘧啶 扑蛲灵;酚嘧啶;奥克太 |
| 英文名称 | OXANTEL PAMOATE |
| 英文同义词 | 2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy-, compd. with 3-(1E)-2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenylphenol (1:1);1-methyl-2-(3-hydroxyphenylethenyl)-1,4,5,6-tetrahydropyrimidine compound with 4,4'-methylenebis(3-hydroxy-2-naphthoic acid);4,4'-Methylenebis(3-hydroxy-2-naphthoic) acid, compound with (E)-3-(2-(1,4,5,6-tetrahydro-1-methylpyrimidin-2-yl)vinyl)phenol (1:1);Einecs 272-332-6;Phenol, 3-(2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenyl), (E)-, 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylate) (1:1) (salt);1-METHYL-2-[3-HYDROXYPHENYLETHENYL]-1,4,5,6-TETRAHYDROPYRIMIDINE COMPOUND WITH 4,4'-METHYLENEBIS[3-HYDROXY-2-NAPHTHOIC ACID];OXANTEL PAMOATE;4,4'-methylenebis[3-hydroxy-2-naphthoic] acid, compound with (E)-3-[2-(1,4,5,6-tetrahydro-1-methylpyrimidin-2-yl)vinyl]phenol (1:1) |
| CAS号 | 68813-55-8 |
| 分子式 | C49H48N4O8 |
| 分子量 | 820.93 |
| EINECS号 | 272-332-6 |
| 相关类别 | 小分子抑制剂;医药原料;有机中间体;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;MOTILIUM |
| Mol文件 | 68813-55-8.mol |
| 结构式 |  |
酚嘧啶 扑蛲灵 性质
| 熔点 | >224°C (dec.) |
|---|---|
| 储存条件 | Amber Vial, Refrigerator, Under inert atmosphere |
| 溶解度 | 可溶于DMSO（略微加热）、甲醇（略微加热） |
| 颜色 | 白色至类白色 |
| InChIKey | WSYDAPQDBDVYIO-QEFJDTIGSA-N |
Antiparasitic
The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris , Ancylostoma ceylanicum and Necator americanus . An ED 50 s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED 50 s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris -infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus .
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B1344 | 酚嘧啶 扑蛲灵 Oxantel pamoate | 68813-55-8 | 100mg | 600元 |
| 2024/01/25 | HY-B1344 | 酚嘧啶 扑蛲灵 Oxantel pamoate | 68813-55-8 | 10mM * 1mLin DMSO | 660元 |