蛋白酶体抑制剂
| 中文名称 | 蛋白酶体抑制剂 |
|---|---|
| 中文同义词 | 乳胞素;蛋白酶体抑制剂;(+)-LACTACYSTIN;蛋白酶体抑制剂 5级;乳酸胱氨酸 |
| 英文名称 | LACTACYSTIN |
| 英文同义词 | (2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBOXY-N-ACETYL-L-CYSTEINE THIOESTER;3S-HYDROXY-2R-(1-HYDROXY-2-METHYLPROPYL)-4R-METHYL-5-OXO-2-PYRROLIDINECARBOXYLATE-N-ACETYL-L-CYSTEINE;(+)-LACTACYSTIN;LACTACYSTIN;LACTACYSTIN (NATIVE);LACTACYSTIN, STREPTOMYCES SP;LACTACYSTIN, SYNTHETIC;N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE |
| CAS号 | 133343-34-7 |
| 分子式 | C15H24N2O7S |
| 分子量 | 376.43 |
| EINECS号 | 200-258-5 |
| 相关类别 | All Inhibitors;Inhibitors;Metabolites;Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases;InhibitorsProtease Inhibitors;Intracellular Protein Degradation;Nitric Oxide and Cell Stress;P to;Protease Inhibitor Specificity Index;Proteasome inhibitor;Proteasome inhibitorEnzyme Inhibitors by Enzyme;Proteasomes;Protease;ProteaseInhibitors |
| Mol文件 | 133343-34-7.mol |
| 结构式 |  |
蛋白酶体抑制剂 性质
| 熔点 | 233-235°C dec. |
|---|---|
| 沸点 | 714.9±60.0 °C(Predicted) |
| 密度 | 1.367±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 可溶于DMSO（高达20mg/ml）、水（高达10mg/ml）或乙醇（高达1mg/ml）。 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 3.11±0.10(Predicted) |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble to 10 mM in water |
| 稳定性 | DMSO或乙醇溶液可在-20°下稳定储存1个月。水溶液不稳定，必须在一个工作日内使用。不应储存水溶液。 |
Lactacystin 是一种抗生素，链霉菌属的代谢物，是一种有效的选择性蛋白酶体 (proteasome) 抑制剂，对 20S 蛋白酶体的 IC50 为 4.8 μM。Lactacystin 还抑制溶酶体酶组织蛋白酶 A。Lactacystin 抑制细胞生长并诱导神经突增生。
IC50: 4.8 μM (proteasome)
Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.
| Animal Model: | Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old |
| Dosage: | 2 µg |
| Administration: | Microinjection |
| Result: | Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice. |
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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