7-胺基去乙酰氧基头胞烷酸
| 中文名称 | 7-胺基去乙酰氧基头胞烷酸 |
|---|---|
| 中文同义词 | 6-氨基屈;7-胺基去乙酰氧基头胞烷酸;6-AMINOCHRYSENE,10NG/UL 标准品;化合物 T13519;6-氨基苯并菲;6-氨基丁烯 |
| 英文名称 | 6-AMINOCHRYSENE |
| 英文同义词 | ADCA;6-Amc;Chrysenex;Chrysonex;6-CHRYSENAMINE;6-AMINOCHRYSENE;AMINOCHRYSENE;AMINOCHRYSENE, 6- |
| CAS号 | 2642-98-0 |
| 分子式 | C18H13N |
| 分子量 | 243.3 |
| EINECS号 | 220-149-7 |
| 相关类别 | |
| Mol文件 | 2642-98-0.mol |
| 结构式 |  |
7-胺基去乙酰氧基头胞烷酸 性质
| 熔点 | 209-211 °C(lit.) |
|---|---|
| 沸点 | 376.18°C (rough estimate) |
| 密度 | 0.8933 (rough estimate) |
| 折射率 | 1.4500 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 丙酮（微溶）、氯仿（微溶）、甲醇（微溶、加热） |
| 酸度系数(pKa) | 4.32±0.30(Predicted) |
| 形态 | 固体 |
| 颜色 | 黄色至棕色 |
| 水溶解性 | 155ug/L(24 ºC) |
| Merck | 13,2275 |
| CAS 数据库 | 2642-98-0(CAS DataBase Reference) |
6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation.
6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer. Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22 |
| 安全说明 | 45-36/37/39-26 |
| WGK Germany | 3 |
| RTECS号 | GC0500000 |
| 海关编码 | 29214900 |
| 提供商 | 语言 |
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