环芬尼
| 中文名称 | 环芬尼 |
|---|---|
| 中文同义词 | 环芬尼;双醋环烷;环己基亚甲基二苯酚二乙酸酯;双氯胍 |
| 英文名称 | Cyclofenil |
| 英文同义词 | 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-phenoacetate;alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-p-cresodiacetate;bis-(p-acetoxyphenyl)-cyclohexylidenemethane;bis-(p-hydroxyphenyl)-cyclohexylidenemethanediacetate;cyclofenyl;cyclophenil;cyclophenyl;f6066 |
| CAS号 | 2624-43-3 |
| 分子式 | C23H24O4 |
| 分子量 | 364.44 |
| EINECS号 | 220-089-1 |
| 相关类别 | 合成;化工原料;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 2624-43-3.mol |
| 结构式 |  |
环芬尼 性质
| 熔点 | 135-136° |
|---|---|
| 沸点 | 415.62°C (rough estimate) |
| 密度 | 1.0986 (rough estimate) |
| 折射率 | 1.4433 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO:10 mg/mLat 60 °C,soluble |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| CAS 数据库 | 2624-43-3(CAS DataBase Reference) |
| Target | Value |
|
ERβ
() | |
|
ERα
() |
Cyclofenil shows an inhibitory effect on dengue virus (DENV) replication in mammalian cells but not in mosquito cells.
Cyclofenil also inhibits the replication of Zika virus. A time-of-addition assay suggested that Cyclofenil may interfere with two stages of the Dengue virus (DENV) life cycle: the translation-RNA synthesis and assembly-maturation stages. The level of intracellular infectious particles decreased more drastically after treatment with Cyclofenil than the viral RNA level do, indicating that the assembly-maturation stage might be the main target of Cyclofenil.
The number of estrogen receptors α (ERα) and β (ERβ)-immunoreactive (-ir) cells is determined of each stage of the estrous cycle in intact rats. Additionally, the effects of blocking ERα and ERβ on ovulation rate on diestrus-2 or proestrus day through the microinjection of methyl-piperidino-pyrazole (MPP) or Cyclofenil in either side of preoptic-anterior hypothalamic area (POA-AHA) are evaluated. The number of ERα-ir and ERβ-ir cells in POA-AHA varied in each phase of estrous cycle. Either MPP or Cyclofenil in the right side of POA-AHA on diestrus-2 day reduced the ovulation rate, while at proestrus day it was decreased in rats treated in either side with MPP, and in those treated with Cyclofenil in the left side. MPP or Cyclofenil produced a decrease in the surge of luteinizing hormone levels (LH) and an increase in progesterone and follicle stimulating hormone (FSH).
安全信息
| WGK Germany | 2 |
|---|---|
| RTECS号 | GO7550000 |
| 毒性 | LD50 oral in rat: > 12gm/kg |