CCG1423
| 中文名称 | CCG1423 |
|---|---|
| 中文同义词 | N-({1-[(4-氯苯基)氨基]-1-氧代-2-丙基}氧基)-3,5-二(三氟甲基)苯甲酰胺;N-[2-[(4-氯苯基)氨基]-1-甲基-2-氧代乙氧基]-3,5-二(三氟甲基)苯甲酰胺;RHOA/C介导基因转录抑制剂(CCG-1423);N-((1-((4-氯苯基)氨基)-1-氧代丙烷-2-基)氧基)-3,5-双(三氟甲基)苯甲酰胺;CCG 1423,RHO / SRF通路抑制剂 |
| 英文名称 | CCG-1423 |
| 英文同义词 | CCG-1423;N-(2-(4-Chloroanilino)-1-Methyl-2-oxoethoxy)-3,5-bis(trifluoroMethyl)benzaMide;N-(1-(4-chlorophenylaMino)-1-oxopropan-2-yloxy)-3,5-bis(trifluoroMethyl)benzaMide;N-({1-[(4-Chlorophenyl)Amino]-1-Oxo-2-Propanyl}Oxy)-3,5-Bis(Trifluoromethyl)Benzamide CCG-1423;N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-benzamide;N-[1-(4-chloroanilino)-1-oxopropan-2-yl]oxy-3,5-bis(trifluoromethyl)benzamide;Rho/SRF Pathway Inhibitor, CCG-1423;CCG-1423 USP/EP/BP |
| CAS号 | 285986-88-1 |
| 分子式 | C18H13ClF6N2O3 |
| 分子量 | 454.75 |
| EINECS号 | |
| 相关类别 | 抑制剂;小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;Inhibitors |
| Mol文件 | 285986-88-1.mol |
| 结构式 |  |
CCG1423 性质
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
|---|---|
| 溶解度 | DMSO：可溶5mg/mL，澄清（加热） |
| 形态 | 白色固体 |
| 颜色 | 白色至米色 |
CCG-1423是一种特定的 RhoA 通路抑制剂，能够抑制SRF介导的转录。CCG-1423 selectively inhibits SRF-mediated transcription activated by Rho pathway signaling, and specifically inhibits LPA-stimulated DNA synthesis. CCG-1423 also selectively inhibits the proliferation of RhoC-overexpressing melanoma cells (A375M2 and SK-Mel-147), and strongly suppresses the Rho-dependent invasion by PC-3 cells. CCG-1423 in combination with LY294002 enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization, and completely blocks STARS proximal reporter activity. CCG-1423, as a Rho/MRTF/SRF pathway inhibitor, also represses both matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts.
安全信息
| WGK Germany | 3 |
|---|---|
| 海关编码 | 2924.29.7790 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-13991 | CCG-1423 | 5 mg | 406元 | |
| 2024/01/25 | HY-13991 | CCG1423 CCG-1423 | 285986-88-1 | 10mg | 650元 |