戊巴比妥 基本信息
中文名称 | 戊巴比妥 |
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中文同义词 | 5-乙基-5-(1-甲基丁基)-2,4,6-(1H,3H,5H)-嘧啶三酮;5-乙基-5-(1-甲基丁基)巴比妥酸;戊巴比妥;戊巴比妥溶液,100PPM;戊巴比妥溶液,1000PPM;硫喷妥钠和碳酸钠EP杂质B;硫喷妥钠EP杂质B;硫喷妥钠杂质B |
英文名称 | Pentobarbital |
英文同义词 | 5-Ethyl-5-(1-methylbutyl)malonylurea;5-Ethyl-5-(sec-pentyl)barbituric acid;5-ethyl-5-(sec-pentyl)barbituricacid;6(1h,3h,5h)-pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-4;Barbituric acid, 5-ethyl-5-(1-methylbutyl)-;barbituricacid,5-ethyl-5-(2-pentyl);component of Emesert;Dorsital |
CAS号 | 76-74-4 |
分子式 | C11H18N2O3 |
分子量 | 226.27 |
EINECS号 | 200-983-8 |
相关类别 | 其它试剂;其他兽药标准品 |
Mol文件 | 76-74-4.mol |
结构式 |
戊巴比妥 性质
熔点 | 129.5°C |
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沸点 | 367.89°C (rough estimate) |
密度 | 1.1376 (rough estimate) |
折射率 | 1.4620 (estimate) |
闪点 | 9℃ |
储存条件 | 2-8°C |
溶解度 | 极微溶于水,易溶于乙醇。它与碱金属氢氧化物和碳酸盐以及氨形成水溶性化合物。 |
形态 | 固体 |
酸度系数(pKa) | pK1:8.11(0) (25°C) |
水溶解性 | 679 mg/L |
CAS 数据库 | 76-74-4(CAS DataBase Reference) |
NIST化学物质信息 | Pentobarbital(76-74-4) |
EPA化学物质信息 | Pentobarbital (76-74-4) |
安全信息
危险品标志 | T,F |
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危险类别码 | 25-63-39/23/24/25-36/38-23/24/25-11 |
安全说明 | 7-16-36/37-45-36/37/39-22 |
危险品运输编号 | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS号 | CQ5775000 |
危险等级 | 6.1(b) |
包装类别 | III |
海关编码 | 2933530000 |
毒害物质数据 | 76-74-4(Hazardous Substances Data) |
毒性 | A barbiturate that causes CNS depression, apparently due to a facilitation of GABA-ergic inhibition. It appears that the site of action of pentobarbital may be the macromolecular complex made up of a GABA receptor, chloride channel, benzodiazepine-binding site, and picrotoxin-binding site. Barbiturates have been shown to compete for dihydropicrotoxinin-binding sites. In clinical use, barbiturates such as pentobarbital have been largely replaced as sedative-hypnotics by the much safer benzodiazepines. The sedative-hypnotic properties of barbiturates may lead to abuse, as tolerance and dependence are known to occur. In animals, pentobarbital is routinely used for its anesthetic and anticonvulsant properties, as well as for euthanasia. Pentobarbital, like other barbiturates, can induce the metabolism of other compounds by altering cytochrome P450 activity. The oral LD50 in rats is 118 mg/kg. |
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