戊巴比妥

戊巴比妥 基本信息

中文名称戊巴比妥
中文同义词5-乙基-5-(1-甲基丁基)-2,4,6-(1H,3H,5H)-嘧啶三酮;5-乙基-5-(1-甲基丁基)巴比妥酸;戊巴比妥;戊巴比妥溶液,100PPM;戊巴比妥溶液,1000PPM;硫喷妥钠和碳酸钠EP杂质B;硫喷妥钠EP杂质B;硫喷妥钠杂质B
英文名称Pentobarbital
英文同义词5-Ethyl-5-(1-methylbutyl)malonylurea;5-Ethyl-5-(sec-pentyl)barbituric acid;5-ethyl-5-(sec-pentyl)barbituricacid;6(1h,3h,5h)-pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-4;Barbituric acid, 5-ethyl-5-(1-methylbutyl)-;barbituricacid,5-ethyl-5-(2-pentyl);component of Emesert;Dorsital
CAS号76-74-4
分子式C11H18N2O3
分子量226.27
EINECS号200-983-8
相关类别其它试剂;其他兽药标准品
Mol文件76-74-4.mol
结构式戊巴比妥 结构式

戊巴比妥 性质

熔点129.5°C
沸点367.89°C (rough estimate)
密度1.1376 (rough estimate)
折射率1.4620 (estimate)
闪点9℃
储存条件2-8°C
溶解度极微溶于水,易溶于乙醇。它与碱金属氢氧化物和碳酸盐以及氨形成水溶性化合物。
形态固体
酸度系数(pKa)pK1:8.11(0) (25°C)
水溶解性679 mg/L
CAS 数据库76-74-4(CAS DataBase Reference)
NIST化学物质信息Pentobarbital(76-74-4)
EPA化学物质信息Pentobarbital (76-74-4)

戊巴比妥 用途与合成方法

安全信息

危险品标志T,F
危险类别码25-63-39/23/24/25-36/38-23/24/25-11
安全说明7-16-36/37-45-36/37/39-22
危险品运输编号UN 2811 6.1/PG 3
WGK Germany3
RTECS号CQ5775000
危险等级6.1(b)
包装类别III
海关编码2933530000
毒害物质数据76-74-4(Hazardous Substances Data)
毒性A barbiturate that causes CNS depression, apparently due to a facilitation of GABA-ergic inhibition. It appears that the site of action of pentobarbital may be the macromolecular complex made up of a GABA receptor, chloride channel, benzodiazepine-binding site, and picrotoxin-binding site. Barbiturates have been shown to compete for dihydropicrotoxinin-binding sites. In clinical use, barbiturates such as pentobarbital have been largely replaced as sedative-hypnotics by the much safer benzodiazepines. The sedative-hypnotic properties of barbiturates may lead to abuse, as tolerance and dependence are known to occur. In animals, pentobarbital is routinely used for its anesthetic and anticonvulsant properties, as well as for euthanasia. Pentobarbital, like other barbiturates, can induce the metabolism of other compounds by altering cytochrome P450 activity. The oral LD50 in rats is 118 mg/kg.

MSDS信息

"戊巴比妥"相关产品信息
正丁基锂 甲酸乙酯 乙醇 4-(二乙氨基)水杨醛 磺胺嘧啶 醋酸生长激素释放肽-2 乙酸乙酯 乙基麦芽酚 羟乙基纤维素 5-氯戊酸 羟乙基淀粉 巴比妥酸 DL-α-生育酚 丁基橡胶 双酚酸 四丁基溴化铵 丙烯酸乙酯 尼泊金乙酯
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