溴隐亭
| 中文名称 | 溴隐亭 |
|---|---|
| 中文同义词 | 2-溴-ALPHA-麦角环肽;溴隐亭(2-溴-ALPHA-麦角环肽);2-溴-12'-羟基-5'-ALPHA-异丁基-2'-异丙基麦角胺-3',6',18-三酮;溴隐亭;溴麦亭;溴麦角隐亭;溴麦角环肽;溴代麦角隐亭碱 |
| 英文名称 | Bromocriptine |
| 英文同义词 | (5’-alpha)-ropyl);,6’,18-trione;2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-alpha-(2-methylpropyl)ergotamin-3’;2-bromo-alpha-ergocryptine;2-bromo-alpha-ergokryptin;2-bromo-alpha-ergokryptine;2-bromoergocryptine;alpha-bromoergocriptine |
| CAS号 | 25614-03-3 |
| 分子式 | C32H40BrN5O5 |
| 分子量 | 654.59 |
| EINECS号 | 247-128-5 |
| 相关类别 | 杂质对照品;有机中间体;Organics |
| Mol文件 | 25614-03-3.mol |
| 结构式 |  |
溴隐亭 性质
| 熔点 | 215-218° (dec) |
|---|---|
| 比旋光度 | D20 -195° (c = 1 in methylene chloride) |
| 沸点 | 891.3±65.0 °C(Predicted) |
| 密度 | 1.2734 (rough estimate) |
| 折射率 | 1.6400 (estimate) |
| 酸度系数(pKa) | pKa 4.90±0.05(80% MCS t = RT) (Uncertain) |
| 水溶解性 | 2.07mg/L(temperature not stated) |
| CAS 数据库 | 25614-03-3(CAS DataBase Reference) |
溴隐亭为特异性下丘脑和垂体的多巴胺受体激动剂，能直接作用于腺垂体，而抑制催乳素的分泌。适合在使用诺龙衍生物的循环中配合使用。
化学性质
白色结晶性粉末。熔点215-218℃（分解）。用途
该品具有多巴胺受体的兴奋作用。可透过血脑屏障，进入中枢神经内，激动多巴胺受体和抑制催乳素及生长激素分泌作用。临床用于帕金森氏症、肢端肥大症和乳溢症等。生产方法
由麦角隐亭和N-溴丁二酸亚胺反应得到。类别
有毒物质急性毒性
高毒刺激数据
静脉-大鼠 LD50: 72 毫克/公斤; 未报导-小鼠 LD50: 200 毫克/公斤可燃性危险特性
热分解排出有毒氮氧化物和溴化物烟雾储运特性
库房通风干燥低温灭火剂
水,二氧化碳,沙土,泡沫,干粉安全信息
| 毒性 | An ergot alkaloid derivative that exhibits potent dopamine agonist properties, particularly at D2 dopamine receptors. Bromocriptine, like dopamine, inhibits prolactin release from the pituitary and so is used in endocrine disorders, such as hyperprolactinemia. It is also used in the treatment of Parkinson’s disease. A large “first-pass” effect is seen with bromocriptine, and peak concentrations occur about 1.5-3 h after ingestion, with a half-life of about 3 h. Nausea, vomiting, and orthostatic hypotension are among the acute adverse effects. Long-term use has been associated with dyskinesias, constipation, psychoses, digital spasm, and erythromelalgia. The LD50 in rabbits exceeds 1 g/kg, p.o., and 12 mg/kg, i.v. |
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