去异丁基环索奈德
中文名称 | 去异丁基环索奈德 |
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中文同义词 | 去异丁基环索奈德;去异丁酸酯环索奈德;环索奈德杂质B;环索奈德EP杂质B;环索奈德杂质B EP标准品;化合物 T13646;环索奈德杂质B(EP);去异丁酰环索奈德 |
英文名称 | Desisobutyryl Ciclesonide |
英文同义词 | 21-Desisobutyryl Ciclesonide;(2′R)-2′-Cyclohexyl-11b,21-dihydroxy-16bH-[1,3]dioxolo[4′,5′:16,17]pregna-1,4-diene-3,20-dione;Ciclesonide impurity B;Desisobutyryl Ciclesonide;(11β,16α)-16,17-[[(R)-CyclohexylMethylene]bis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione;CIC-AP;Ciclesonide active principle;Ciclesonide EP Impurity B |
CAS号 | 161115-59-9 |
分子式 | C28H38O6 |
分子量 | 470.61 |
EINECS号 | |
相关类别 | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
Mol文件 | 161115-59-9.mol |
结构式 |
去异丁基环索奈德 性质
熔点 | 129-132?C |
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沸点 | 640.8±55.0 °C(Predicted) |
密度 | 1.28±0.1 g/cm3(Predicted) |
储存条件 | -20°C Freezer |
溶解度 | 可溶于氯仿(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 12.87±0.10(Predicted) |
颜色 | 白色至类白色 |
Glucocorticoid receptor
Ciclesonide, an inhaled corticosteroid with almost no affinity for the glucocorticoid receptor, is highly effective in downregulating in vitro pro-inflammatory activities of airway parenchymal cells when converted into the active metabolite Desisobutyryl-ciclesonide. Peripheral blood mononuclear cell proliferation to C. albicans is dose-dependently inhibited by 0.3-3.0 μM Ciclesonide and Desisobutyryl-ciclesonide but inhibition by Desisobutyryl-ciclesonide is higher. A significant proliferation to PhlP5 is observed only in cultures from atopic subjects: an effective downregulation is already detected at 0.03 μM Ciclesonide and 0.003 μM Desisobutyryl-ciclesonide (complete inhibition at 3 μM Ciclesonide and 0.03 μM Desisobutyryl-ciclesonide). 3 μM Ciclesonide and Desisobutyryl-ciclesonide reduce the PhlP5 -specific T-cell blast proliferation and interleukin 4-producing cell proportion. In PBMCs cultures from atopic patients, both Ciclesonide (CIC) and Desisobutyryl-ciclesonide (des-CIC) induce a dose-dependent downregulation of PhlP5 -induced proliferation. The effect is already significantat 0.03 μM Ciclesonide and at 0.003 μM Desisobutyryl-ciclesonide (p<0.001, each comparison),with an early complete inhibition observed at 3μM Ciclesonide and at 0.03 μM Desisobutyryl-ciclesonide. The inhibitory activity toward PhlP5 -induced PBMC proliferation is higher for Desisobutyryl-ciclesonide than for Ciclesonide at 0.003 μM (p<0.05), 0.03 μM (p<0.001) and 0.3 μM (p<0.05).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-111490 | 去异丁基环索奈德 Desisobutyryl-ciclesonide | 161115-59-9 | 5mg | 900元 |
2024/08/19 | HY-111490 | 去异丁基环索奈德 Desisobutyryl-ciclesonide | 161115-59-9 | 10mM * 1mLin DMSO | 932元 |