硫酸原黄素
中文名称 | 硫酸原黄素 |
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中文同义词 | 原黄素 半硫酸盐;原黄素 单盐酸盐;硫酸原黄素/硫酸二氨基吖啶黄;硫酸原黃素;硫酸原黄素;硫酸二氨基吖啶黄;3,6-二氨基吖啶半硫酸盐;硫酸原黄素水合物 |
英文名称 | PROFLAVINE HEMISULFATE |
英文同义词 | PROFLAVINE HEMISULFATE SALT HYDRATE(RG);Proflavine hemisulfate salt dihydrate;3,6-acridinediamine,sulfate(2:1);3,6-diamino-acridinsulfate(2:1);PROFLAVINE SULFATE;PROFLAVINE HEMISULFATE;3,6-DIAMINOACRIDINE SULFATE;3,6-DIAMINOACRIDINE HEMISULFATE |
CAS号 | 1811-28-5 |
分子式 | C13H13N3O4S |
分子量 | 307.32 |
EINECS号 | 217-320-3 |
相关类别 | 小分子抑制剂,天然产物;小分子抑制剂;原料药;原药中间体;Inhibitors;Miscellaneous;Biochemistry;Vitamin Derivatives;Vitamins |
Mol文件 | 1811-28-5.mol |
结构式 |
硫酸原黄素 性质
储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
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溶解度 | DMSO(稍微加热)、水(稍微加热) |
形态 | 粉末 |
颜色 | 橙色到琥珀色到深红色 |
PH值 | pH (1g/l, 25℃) : 4.0~8.0 |
BRN | 3921806 |
稳定性 | 吸湿性 |
EPA化学物质信息 | 3,6-Acridinediamine, sulfate (2:1) (1811-28-5) |
Proflavine Hemisulfate是一种外用防腐剂,通过与DNA螯合从而破坏DNA合成,且导致复制的DNA链发生高水平的突变。
Proflavine作为一种Rev抑制剂,通过靶向结合高亲和力的Rev结合位点,HIV-1的Rev响应要素而发挥作用。
The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing.
Animal Model: | Adult male Sprague Dawley rats (weighing approximately 200 g) |
Dosage: | 20 mg/kg (Pharmacokinetic Analysis) |
Administration: | Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing |
Result: | Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease. |