1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
生物活性靶点体内研究 用途与合成方法 MSDS 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride价格(试剂级) 上下游产品信息
| 中文名称 | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride |
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| 中文同义词 | 盐酸左卡巴司丁;3-(3,4-二羟基苯基)-L-丙氨酸;3-羟基酪氨酸;L-Β-(3,4-二羟基苯基)初油氨基酸;L-Β-3,4-二羟基苯丙氨酸;左卡巴斯汀盐酸盐;左卡巴斯汀,用于系统适应性1 EP标准品;盐酸左卡巴斯汀 EP标准品 |
| 英文名称 | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride |
| 英文同义词 | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride;R50547;LIVOSTIN;[3s-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid;4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, [3S-[1(cis),3a,4b]]-;4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)- (9CI);Levophta, Levostin, R50547, [3S-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid;LEVOPHTA |
| CAS号 | 79547-78-7 |
| 分子式 | C26H30ClFN2O2 |
| 分子量 | 456.99 |
| EINECS号 | 209-062-5 |
| 相关类别 | 医药原料;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 79547-78-7.mol |
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1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 性质
| 储存条件 | 2-8°C |
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| 溶解度 | DMSO：~10 mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 用途与合成方法
Levocabastine hydrochloride (R 50547) 是一种具有抗过敏活性的长效、高效、选择性组胺 H1 受体拮抗剂。Levocabastine hydrochloride 也是一种选择性、高亲和力的神经降压素受体亚型2 (NTR2) 拮抗剂，对 mNTR2 的 Ki 值为 17 nM。
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H 1 Receptor
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NTR2 17 nM (Ki) |
Levocabastine (0.25 mg/kg; i.p.; twice a day for five successive days; guinea-pigs) inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan.
In mice that receivedβ-LT, Levocabastine (0.05 mg/kg; i.p.) blocks the anxiolytic effect of β-LT and the number of head-dips decreased.
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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| 2024/01/25 | HY-14277A | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Levocabastine hydrochloride | 79547-78-7 | 5mg | 2700元 |