L-去甲肾上腺素酒石酸氢盐(酯)
中文名称 | L-去甲肾上腺素酒石酸氢盐(酯) |
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中文同义词 | (-)-(R)-除肾上腺素氢化酒石酸盐一水;DL-NOREPINEPHRINE (2,5,6, Α-D2,Β-D1) D6旽CL;L-去甲肾上腺素酒石酸氢盐(酯);化合物 T20173;L-去甲肾上腺素重酒石酸盐;(-)-ARTERENOL BITARTRATE SALT;肾上腺素EP杂质B |
英文名称 | L-NORADRENALINE BITARTRATE |
英文同义词 | (-)-noradrenalineacidtartrate;(-)-noradrenalinebitartratemonohydrate;Noradrenalineacidtartrate;noradrenalinehydrogentartrate;noradrenalinetartrate;norepinephrinehydrogentartrate;L-NORADRENALINE BITARTRATE;L-4-(A-HYDROXY-B-AMINOETHYL)CATECHOL BITARTRATE |
CAS号 | 51-40-1 |
分子式 | C8H11NO3.C4H6O6 |
分子量 | 319.26 |
EINECS号 | 200-095-0 |
相关类别 | 有机化工原料;Standards - 13C & 2H for GC-Mass Spectrometry |
Mol文件 | 51-40-1.mol |
结构式 |
L-去甲肾上腺素酒石酸氢盐(酯) 性质
储存条件 | Store at 4°C, protect from light |
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溶解度 | DMSO 中 31.93mg/mL |
酸度系数(pKa) | 8.64(at 25℃) |
熔点 | 102-104 °C |
水溶解性 | 31.93mg/mL in Water |
CAS 数据库 | 51-40-1(CAS DataBase Reference) |
EC50: 5.37 μM (β 1 -selective adrenergic receptor).
Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β 1 -subtype selective adrenergic agonist. Norepinephrine (NE) also has direct activity at the β 2 -adrenoceptor in higher concentrations. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effectNorepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA.
RT-PCR
Cell Line: | Subcutaneous preadipocytes Adipocytes. |
Concentration: | 10 μM. |
Incubation Time: | 6 hours. |
Result: | AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA) |
安全信息
危险品运输编号 | 3249 |
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危险等级 | 6.1(b) |
包装类别 | III |
毒性 | LD50 ivn-rat: 210 mg/kg YACHDS 7,627,79 |