糖尿病相关肽(胰岛淀粉样肽)(抗原)
| 中文名称 | 糖尿病相关肽(胰岛淀粉样肽)(抗原) |
|---|---|
| 中文同义词 | 糖尿病相关肽(胰岛淀粉样肽)(抗体);安林肽;糖尿病相关肽(胰岛淀粉样肽)(抗原);糖尿病相关肽(胰岛淀粉样肽);糊精肽;糖尿病相关肽(胰岛淀粉样肽), ≥97% (HPLC);糖尿病相关肽;胰淀素受体AMYLIN, AMIDE, HUMAN |
| 英文名称 | AMYLIN, HUMAN |
| 英文同义词 | KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 (DISULFIDE BRIDGE: 2-7);LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-HIS-SER-SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2;DIABETES ASSOCIATED PEPTIDE AMIDE HUMAN;DIABETES-ASSOCIATED PEPTIDE (DAP) AMIDE, HUMAN;DIABETES-ASSOCIATED PEPTIDE HUMAN;DAP (HUMAN);DAP AMIDE, HUMAN;DAP |
| CAS号 | 122384-88-7 |
| 分子式 | C8H17O3* |
| 分子量 | 161.21878 |
| EINECS号 | |
| 相关类别 | 细胞生物学;多肽;细胞信号和神经生物学;生化试剂-蛋白质;试剂盒-Elisa试剂盒;Peptide;proteins |
| Mol文件 | 122384-88-7.mol |
| 结构式 |  |
糖尿病相关肽(胰岛淀粉样肽)(抗原) 性质
| 储存条件 | -20°C |
|---|---|
| 形态 | 固体 |
| 水溶解性 | Soluble to 5 mg/ml in water and in 5% acetic acid. |
Amylin, amide, human 是一种 37 个氨基酸的多肽，是一种与胰岛素共分泌的胰腺激素，在代谢和葡萄糖稳态中发挥独特作用。Amylin, amide, human 抑制胰高血糖素分泌，延迟胃排空，并作为饱腹感剂。
MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC 50 of 35.2±7.5 nM.
Cell Viability Assay
| Cell Line: | MCF-7 cells |
| Concentration: | 0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10μM, 100 μM, 1000 μM |
| Incubation Time: | |
| Result: | Resulted in the production of cAMP with an EC 50 of 35.2±7.5 nM. |
Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min.
| Animal Model: | Swiss male mice (8 weeks old) |
| Dosage: | 400 μg peptide /kg body weight (Pharmacokinetic Analysis) |
| Administration: | Subcutaneous route; 24 hours |
| Result: | Half-time of 23 min. |
安全信息
| WGK Germany | 3 |
|---|---|
| 海关编码 | 2937190000 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-P1070 | 糖尿病相关肽(胰岛淀粉样肽)(抗原) Amylin, amide, human | 122384-88-7 | 500μg | 2400元 |
| 2024/01/25 | HY-P1070 | 糖尿病相关肽(胰岛淀粉样肽)(抗原) Amylin, amide, human | 122384-88-7 | 1mg | 3850元 |