菝葜
| 中文名称 | 菝葜 |
|---|---|
| 中文同义词 | 菝葜配質;异菝葜皂甙;菝葜配基;菝葜;异知母皂苷元;化合物 T4954L;异菝葜皂苷 |
| 英文名称 | SMILAGENIN |
| 英文同义词 | SMILAGENIN;(25r)-spirostan-3β-ol;(25R)-Spirostan-3β-ol, 16,22:22,26-Bis(epoxy)cholestan-3β-ol;5.beta.-Spirostan-3.beta.-ol, (25R)-;Nsc93747;Spirostan-3-ol, (3.beta.,5.beta.,25R)-;(3β,5β,25R)-Spirostan-3-ol;16,22:22,26-Bis(epoxy)cholestan-3β-ol |
| CAS号 | 126-18-1 |
| 分子式 | C27H44O3 |
| 分子量 | 416.64 |
| EINECS号 | 204-775-8 |
| 相关类别 | 中草药成分;比列产品;Steroids |
| Mol文件 | 126-18-1.mol |
| 结构式 |  |
菝葜 性质
| 熔点 | ~185 °C |
|---|---|
| 比旋光度 | D25 -69° (c = 0.5 in chloroform) |
| 沸点 | 474.91°C (rough estimate) |
| 密度 | 1.0362 (rough estimate) |
| 折射率 | 1.4700 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 乙醇：≥ 10 mg/mL (24.00 mM)； DMSO：< 1 mg/mL（不溶或微溶） |
| 酸度系数(pKa) | 15.14±0.70(Predicted) |
Smilagenin (SMI) 是一种脂溶性小分子甾体皂苷元，来自知母 Rhizoma anemarrhenae 和天竺葵 Radix asparagi，广泛用于慢性神经退行性疾病的研究。Smilagenin (SMI) 通过增加毒蕈碱受体亚型 1 (M1)-受体的的密度来改善老年大鼠的记忆。
Smilagenin (SMI) 通过刺激脑源性神经营养因子的基因表达减弱 Aβ (25-35) 诱导的神经变性，可用于 AD 的研究。
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Human Endogenous Metabolite
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Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells. Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP + ) treated SH-SY5Y cells.
Cell Viability Assay
| Cell Line: | SH-SY5Y cells |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours |
| Result: | Elevated the SH-SY5Y cell viability. |
RT-PCR
| Cell Line: | SH-SY5Y cells |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours |
| Result: | Increased GDNF and BDNF transcription. |
Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model.
| Animal Model: | MPTP/probenecid-induced mouse model |
| Dosage: | 10 or 26 mg/kg |
| Administration: | Intragastric administration; 10 or 26 mg/kg; once daily; 60 days |
| Result: | Ameliorated locomotor ability of MPTP/probenecid-lesioned mice. |
安全信息
| WGK Germany | 3 |
|---|---|
| F | 10 |
| 提供商 | 语言 |
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英文
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