青蒿酮
中文名称 | 青蒿酮 |
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中文同义词 | 青蒿酮;13C4]-青蒿素 |
英文名称 | Artemifone |
英文同义词 | Artemifone;10alpha-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin;Artemisone;BAY 44-9585;YHVQDGXHTCSGBJ-AKSSTEKGSA-N;4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide;Thiomorpholine, 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]-, 1,1-dioxide;Cytomegalovirus,Inhibitor,Parasite,CMV,inhibit,Artemisone |
CAS号 | 255730-18-8 |
分子式 | C19H31NO6S |
分子量 | 401.52 |
EINECS号 | |
相关类别 | |
Mol文件 | 255730-18-8.mol |
结构式 |
青蒿酮 性质
沸点 | 536.5±50.0 °C(Predicted) |
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密度 | 1.33±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:130 mg/mL(323.77 mM) |
酸度系数(pKa) | 2.99±0.20(Predicted) |
IC50: 0.83 nM ( P. falciparum )
Artemisone inhibits 3D7 and K1 P. falciparum , with IC 50 s of 0.88±0.59 and 1.23±0.64 nM, respectively.
Artemisone is effectve at inhibiting the parasitaemia in the
P. berghei
NY susceptible strain, with an ED
50
of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration.
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line
P. yoelii
NS
安全信息
海关编码 | 9999999999 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-19502 | Artemisone | 1 mg | 1333元 | |
2024/01/25 | HY-19502 | 青蒿酮 Artemisone | 255730-18-8 | 5mg | 3500元 |