奎诺二甲基丙烯酸酯
| 中文名称 | 奎诺二甲基丙烯酸酯 |
|---|---|
| 中文同义词 | 奎诺二甲基丙烯酸酯;奎诺二甲基丙烯酸;水溶性维生素E/奎诺二甲基丙烯酸酯;奎诺二甲基丙烯酸酯(TROLOX);6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-羧酸;6-羟基-2,5,7,8-四甲基色满-2-羧酸(97%);(±)-6-羟基-2,5,7,8-四甲基色满-2-羧酸;(±)-6-羟基-2,5,7,8-四甲基色烷-2-羧酸 |
| 英文名称 | Trolox |
| 英文同义词 | 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2-carboxylicaci;troloxc;6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID;(+/-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID;TROLOX(R);TROLOXTM C;TIMTEC-BB SBB005933;trolox tm |
| CAS号 | 53188-07-1 |
| 分子式 | C14H18O4 |
| 分子量 | 250.29 |
| EINECS号 | 258-422-8 |
| 相关类别 | 合成;小分子抑制剂;有机化合物;有机化工原料;体外诊断试剂;诊断试剂系列-诊断试剂系列;化学原料;化工产品-有机化工;化工原料 |
| Mol文件 | 53188-07-1.mol |
| 结构式 |  |
奎诺二甲基丙烯酸酯 性质
| 熔点 | 187-189 °C (lit.) |
|---|---|
| 沸点 | 313.42°C (rough estimate) |
| 密度 | 1.0616 (rough estimate) |
| 折射率 | 1.4970 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于DMSO（高达25mg/ml）或乙醇（高达25mg/ml）。在碱性pH值下也可溶于水。 |
| 形态 | 结晶粉末 |
| 酸度系数(pKa) | 3.35±0.20(Predicted) |
| 颜色 | 白色至淡米色 |
| BRN | 1384051 |
| 稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达1个月。 |
| InChI | InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17) |
| InChIKey | GLEVLJDDWXEYCO-UHFFFAOYSA-N |
| SMILES | C1(C)(C(O)=O)OC2=C(C)C(C)=C(O)C(C)=C2CC1 |
| CAS 数据库 | 53188-07-1(CAS DataBase Reference) |
| EPA化学物质信息 | 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid (53188-07-1) |
Trolox has shown to protect mammalian cells from oxidative damage. Trolox is effective in preventing myocyte necrosis in cell culture studies and in a canine model of two hours of left anterior descending coronary artery (LAD) occlusion followed by four hours of reperfusion.
Trolox could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or posttreatment of cells with Trolox reduced H
2
O
2
-induced DNA fragmentation to control levels and below. .
Trolox is a hydrophilic analogue of alpha-tocopherol and reported to scavenge peroxyl radicals better than vitamin E in sodium dodecyl sulfate micelles and in liposomes. Trolox prolongs substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator.
一种来源于水溶性维生素e的抗氧化剂,具有自由基清除和抗氧化活性。
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