2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
| 中文名称 | 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 |
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| 中文同义词 | 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺;去乙酰化酶;2-[(2-羟基萘-1-基亚甲基)氨基]-N-(1-苯乙基)苯甲酰胺;SIRTINOL, 去乙酰化酶;SIRTUIN抑制剂(SIRTINOL);西丁醇 |
| 英文名称 | SIRTINOL |
| 英文同义词 | 2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE;SIRTINOL;SIR TWO INHIBITOR NAPHTHOL;(E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide;2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide;2-{[(2-hydroxynaphthalen-1-yl)Methylidene]aMino}-N-(2-phenylethyl)benzaMide;{2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]}-N-(1-phenethyl)benzamide (Sirtinol);Sirtinol - CAS 410536-97-9 - Calbiochem |
| CAS号 | 410536-97-9 |
| 分子式 | C26H22N2O2 |
| 分子量 | 394.47 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;细胞生物学试剂;Inhibitors;Inhibitor;Other Enzyme Inhibitors.;Other enzyme inhibitors and activators |
| Mol文件 | 410536-97-9.mol |
| 结构式 | ![2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 结构式](CAS/GIF/410536-97-9.gif) |
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 性质
| 熔点 | 119-120℃ |
|---|---|
| 沸点 | 659.2±50.0 °C(Predicted) |
| 密度 | 1.16 |
| 储存条件 | -20°C |
| 溶解度 | 溶于 DMSO（高达 30 mg/ml）。 |
| 形态 | 黄色固体 |
| 酸度系数(pKa) | 7.85±0.50(Predicted) |
| 颜色 | 淡黄色低 |
| 水溶解性 | Soluble in water, DMSO and methanol |
| 稳定性 | 可在-20°下的DMSO中的溶液储存长达1个月。 |
|
ySir2 48 μM (IC 50 ) |
hSIRT2 57.7 μM (IC 50 ) |
hSIRT1 131 μM (IC 50 ) |
Sirtinol reduces the growth of MCF-7 cells in a concentration- and time-dependent manner. The IC 50 values of sirtinol are 48.6 μM and 43.5 μM after 24 and 48 h of treatment, respectively. Sirtinol significantly decreases SIRT1 expression and increases the acetylated p53 level. Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1.
Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury.
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-13515 | Sirtinol | 1 mg | 250元 | |
| 2024/01/25 | HY-13515 | 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 Sirtinol | 410536-97-9 | 5mg | 550元 |