CKD-602 盐酸盐
| 中文名称 | CKD-602 盐酸盐 |
|---|---|
| 中文同义词 | 盐酸贝路替康;盐酸贝洛替康;CKD-602 盐酸盐;(S)-4-乙基-4-羟基-11-[2-(异丙基氨基)乙基]-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]中氮茚并[1,2-B]喹啉-3,14-二酮盐酸盐;(S)-4-乙基-4-羟基-11-[2-(异丙基氨基)乙基]-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]氮茚并[1,2-B]喹啉-3,14-二酮盐酸盐;(S)-4-乙基-4-羟基-11-(2-(异丙氨基)乙基)-1H-吡喃并[3',4'：6,7]吲哚并[1-2,b]喹啉-3,14(4H,12H)-二酮盐酸盐;TOPOISOMERASE I抑制剂(BELOTECAN HYDROCHLORIDE);贝洛替康盐酸盐 |
| 英文名称 | Camtobell hydrochloride |
| 英文同义词 | BELOTECAN HYDROCHLORIDE;CKD-602: BELOTECAN HYDROCHLORIDE;(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione hydrochloride;Camtobell hydrochloride;(S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol;Belotecan hydrochloride(CKD-602);Belotecan HCl;Belotecan Hydrochlorid |
| CAS号 | 213819-48-8 |
| 分子式 | C25H28ClN3O4 |
| 分子量 | 469.97 |
| EINECS号 | |
| 相关类别 | 医药中间体;细胞生物学试剂;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 213819-48-8.mol |
| 结构式 |  |
CKD-602 盐酸盐 性质
| 熔点 | >218°C (dec.) |
|---|---|
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | DMSO（轻微）、甲醇（轻微、加热）、水（轻微） |
| 形态 | 固体 |
| 颜色 | 浅米色至浅棕色 |
CKD-602 盐酸盐是一种新型喜树碱衍生物抗肿瘤药物。尽管ckd -602在临床中应用更广泛，但静脉输注引起的ckd -602相关毒性尚未得到评估。
Belotecan (CKD-602)是有效的DNA topoisomerase I抑制剂，可对多种类型的肿瘤发挥抗癌活性。| Target | Value |
|
DNA topoisomerase I
() |
Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC 50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC 50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.
Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-13566A | Belotecan hydrochloride | 1 mg | 548元 | |
| 2024/01/25 | HY-13566A | CKD-602 盐酸盐 Belotecan hydrochloride | 213819-48-8 | 5mg | 1200元 |