IBERIOTOXIN毒素肽 CAS#: 129203-60-7

IBERIOTOXIN毒素肽

生物活性靶点体外研究体内研究用途与合成方法 MSDS IBERIOTOXIN毒素肽价格(试剂级) 上下游产品信息

中文名称	IBERIOTOXIN毒素肽
中文同义词	IBERIOTOXIN毒素肽;毒素多肽IBERIOTOXIN;伊贝毒素;伊比蝎毒素;伊比(利亚)蝎毒素
英文名称	IBERIOTOXIN
英文同义词	PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN;iberiotoxin from buthus tamulus;IBERIOTOXIN, RECOMBINANT;IBERIOTOXIN 98%;PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH;PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH (DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35);M.W. 4230.91 C179H274N50O55S7;pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH
CAS号	129203-60-7
分子式	C179H274N50O55S7
分子量	4230.84786
EINECS号
相关类别	原料药;毒素肽;标准品;目录多肽;Enzyme Inhibitors;Enzyme Inhibitors by Type;Other;Monovalent Ion Channels;Potassium Channel ModulatorsCell Signaling and Neuroscience;Scorpion;Toxins and Venoms;Voltage-gated Ion Channels;Ion Channel Modulating Peptides;Potassium Channel ModulatorsPeptides for Cell Biology;Potassium channel
Mol文件	129203-60-7.mol
结构式

IBERIOTOXIN毒素肽性质

储存条件	-20°C
溶解度	H₂O：1 mg/mL，澄清，无色
形态	游离固体盐
水溶解性	Soluble to 0.70 mg/ml in water

IBERIOTOXIN毒素肽用途与合成方法

生物活性

Iberiotoxin 是一种从 Buthus tamulus 毒液中分离出来的毒素。Iberiotoxin 是一种选择性的高电导率 Ca2+ 激活的 K+ 通道 (Ca2+-activated K+ channel) 抑制剂，Kd 约为 1 nM。Iberiotoxin 不阻断其他类型的电压依赖性离子通道。

靶点

Kd: 1 nM (Ca ²⁺ -activated K ⁺ channel)

体外研究

Iberiotoxin reversibly blocks Ca2+-activated K+ channel in excised membrane patches from bovine aortic smooth muscle. Iberiotoxin acts exclusively at the outer face of the channel and functions with IC ₅₀ values of about 250 pM. Iberiotoxin is a partial inhibitor of ¹²⁵ I-charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (Ki of 2 ₅₀ pM). Iberiotoxin functions as a noncompetitive inhibitor of charybdotoxin binding.
Iberiotoxin treatment affects rat mesenchymal stem cells (rMSCs) migration in the absence of platelet lysate (PL) by inducing a decrease in cell migration suggesting that BK channels regulate rMSCs migration in basal conditions. 10 nM of Iberiotoxin abolishes the PL-induced migration effect on MSCs.

体内研究

Male Wistar rats (6-7 weeks old) with chronic heart failure (CHF), Iberiotoxin (0.125 nmol/nl, 1.25 nmol/nl and 12.5 nmol/nl) is infused into paraventricular hypothalamic nucleus (PVN) by osmotic minipumps. After perfusion of Iberiotoxin by microinjection of rAAV2-KCNMB4 shRNA virus, right ventricular weight/body weight and lung weight/body weight ratio as well as left ventricular end-diastolic diameter are increased and left ventricular ejection fraction is decreased.

安全信息

危险品标志	T+
危险类别码	26/27/28
安全说明	28-36/37-45
危险品运输编号	UN 3462 6.1/PG 2
WGK Germany	3
RTECS号	NH6107500
F	3-10

MSDS信息

提供商	语言
SigmaAldrich	英文

IBERIOTOXIN毒素肽价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/01/25	HY-P0190	IBERIOTOXIN毒素肽 Iberiotoxin	129203-60-7	100μg	3800元

IBERIOTOXIN毒素肽