准葛尔乌头碱
中文名称 | 准葛尔乌头碱 |
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中文同义词 | 准葛尔乌头碱;雪上一枝蒿 G;宋果灵(准格尔乌头碱);宋果灵(华北乌头碱、一枝蒿庚素;准噶尔乌头碱;准格尔乌头碱;华北乌头碱;宋果灵(华北乌头碱、一枝蒿庚素)(标准品) |
英文名称 | songorine |
英文同义词 | (20R)-21-Ethyl-1α,15β-dihydroxy-4-methyl-16-methylene-7α,20-cycloveatchan-12-one;Napellonine;Zongorine;(3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-Ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one;Napellonin;Xuan-Wu 2;Songorine,BullatineG;ShiMoburo base I |
CAS号 | 509-24-0 |
分子式 | C22H31NO3 |
分子量 | 357.49 |
EINECS号 | 200-158-5 |
相关类别 | 标准品;中药对照品;对照品;植物提取物;标准品-对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;生物碱;标准品 -中药标准品;标准品,对照品 |
Mol文件 | 509-24-0.mol |
结构式 |
准葛尔乌头碱 性质
熔点 | 201-203℃ |
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比旋光度 | D20 -135.4° |
沸点 | 535.8±50.0 °C(Predicted) |
密度 | 1.29 |
溶解度 | DMF:10mg/mL; DMF:PBS (pH 7.2) (1:4):0.20 mg/ml; DMSO:5mg/mL;乙醇:微溶 |
形态 | 固体 |
酸度系数(pKa) | 14.20±0.60(Predicted) |
IC50: GABAA receptor
Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax. Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD 50 and ED 50 values of 142 mg and 7.3mg, respectively.
药理药效:1.对中枢神经系统的作用:宋果灵400mg/kg皮下注射,可降低小鼠自发活动,对兔有微弱的镇静作用。能延长小鼠用催眠药引起的麻醉时间,对兔有降温作用。高剂量时抑制、低剂量时刺激中枢神经,产生兴奋作用;2.其他作用:准噶尔乌头碱大剂量可阻断神经节显示降压作用,小剂量则翻转利血平的降压作用。具有抗乙酰胆碱和加强肾上腺素的作用。3.毒性:小鼠LD50 (mg/kg):灌胃1575,皮下注射630,腹腔注射485,静脉注射142.5。对大鼠长期给50mg/kg剂量,其心、肝、肾、脑等均出现毒性变化。
安全信息
毒性 | LD50 in mice (mg/kg): 1575 orally, 630 s.c., 485 i.p., 142.5 i.v.; in rats (mg/kg): 407.5 i.p. (Bisset) |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/16 | S9065 | 准葛尔乌头碱 Songorine | 509-24-0 | 1mg | 1204.89元 |