莪术呋喃烯
| 中文名称 | 莪术呋喃烯 |
|---|---|
| 中文同义词 | 莪术烯;CURZERENE 莪术烯;莪术呋喃烯;莪术烯莪术烯;莪术烯(黄色油状液体);莪术烯对照品;莪术烯标准品 |
| 英文名称 | Curzerene |
| 英文同义词 | Curzerene;Isofuranogermacrene;Isogermafurene;Isogermafuren;Neocurzerene;Benzofuran, 6-ethenyl-4,5,6,7-tetrahydro-3,6-dimethyl-5-(1-methylethenyl)-, (5R,6R)-rel- |
| CAS号 | 17910-09-7 |
| 分子式 | C15H20O |
| 分子量 | 216.32 |
| EINECS号 | |
| 相关类别 | 中药对照品;标准品;对照品,标准品;对照品;植物提取物;对照品-中药对照品;标准品 -中药标准品;标准品，对照品;化工原料 |
| Mol文件 | 17910-09-7.mol |
| 结构式 |  |
莪术呋喃烯 性质
| 沸点 | 282.8±40.0℃ (760 Torr) |
|---|---|
| 密度 | 0.982±0.06 g/cm3 (20 ºC 760 Torr) |
| 闪点 | 117.5±14.2℃ |
| 溶解度 | 溶于氯仿 |
| 形态 | 液体 |
| 颜色 | 黄色油状 |
| LogP | 3.982 (est) |
GSTA1
Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC 50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively. Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells. Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose. Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells. Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells.
Cell Viability Assay
| Cell Line: | SPC-A1 cells |
| Concentration: | 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro. |
Apoptosis Analysis
| Cell Line: | SPC-A1 cells |
| Concentration: | 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM |
| Incubation Time: | 48 hours |
| Result: | Induced apoptosis of the cells in a dose-dependent manner. |
Apoptosis Analysis
| Cell Line: | SPC-A1 cells |
| Concentration: | 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM |
| Incubation Time: | 48 hours |
| Result: | Induced G2/M cell cycle arrest of SPC A1 cells. |
RT-PCR
| Cell Line: | SPC-A1 cells |
| Concentration: | 6.25 µM, 25 µM, 100 µM |
| Incubation Time: | 48 hours |
| Result: | Decreased GSTA1 mRNA expression. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N1963 | 莪术呋喃烯 Curzerene | 17910-09-7 | 1mg | 500元 |
| 2024/01/25 | HY-N1963 | Curzerene | 1 mg * 5 | 1600元 |