氯吡硫磷一氧
中文名称 | 氯吡硫磷一氧 |
---|---|
中文同义词 | 毒死蜱氧化物;毒死碑代谢物;氯吡硫磷一氧;毒死蜱氧化物 标准品;毒死蜱氧化物(5598-15-2) 标准品;毒死蜱杂质标样A |
英文名称 | CHLORPYRIFOS-OXON |
英文同义词 | 3,5,6-Trichloro-2-pyridyl diethyl phosphate;Chloropyrifos oxon;Chloropyrifos oxygen analog;chloropyrifosoxon;chlorpyrifos oxygen analogue;Chlorpyrifos Oxon 100mg [5598-15-2];6-Trichloro-2-pyridyl Diethyl Phosphate;Chlorpyrifos-ethyl Oxon |
CAS号 | 5598-15-2 |
分子式 | C9H11Cl3NO4P |
分子量 | 334.52 |
EINECS号 | |
相关类别 | 标准品;有机氯杀虫剂;杀虫剂;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Phosphorylating and Phosphitylating Agents |
Mol文件 | 5598-15-2.mol |
结构式 |
氯吡硫磷一氧 性质
沸点 | 357.8±42.0 °C(Predicted) |
---|---|
密度 | 1.461±0.06 g/cm3(Predicted) |
储存条件 | 0-6°C |
溶解度 | 可溶于氯仿(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | -5.28±0.10(Predicted) |
颜色 | 灰白色至浅米色 |
水溶解性 | 0.52g/L(24 ºC) |
稳定性 | 吸湿性、湿敏性 |
EPA化学物质信息 | Chlorpyrifos O.A. (5598-15-2) |
Treatment of tubulin with 1.5 mM Chlorpyrifos-oxon (CPO) leads to protein aggregation. However, even at 1.5 μM Chlorpyrifos-oxon cross-linked trimers are apparent. Chlorpyrifos-oxon promotes isopeptide bond cross-linking of tubulin monomers to make multimers.
In PC12 cells in culture, 24 hours of exposure to Chlorpyrifos at a concentration 10-fold below the concentration that inhibits AChE activity (3.0 μM) impaired neurite outgrowth while Chlorpyrifos-oxon inhibits neurite outgrowth at 1.0 nM.
Chlorpyrifos-oxon (CPO) is rapidly detoxified by human liver microsomes via CYP-dependent deethylation and dearylation, and by glutathione-S-transferase. In addition, reactions with A-esterases such as paraoxonase 1 (PON 1) or B-esterases such as carboxylesterase and butyrylcholinesterase (BChE) in the liver may rapidly degrade or scavenge Chlorpyrifos-oxon.
Chlorpyrifos-oxon (3 mg/kg, ip; once; wild-type mice) treatment shows the dimensions of microtubules from Chlorpyrifos-oxon-treated mice are about 60% of those from control mice. The microtubules from mice exposed to Chlorpyrifos-oxon have covalently modified amino acids and abnormal structure, suggesting disruption of microtubule function.
安全信息
危险品运输编号 | 2783 |
---|---|
危险等级 | 6.1(b) |
包装类别 | III |