HDAC6抑制剂
| 中文名称 | HDAC6抑制剂 |
|---|---|
| 中文同义词 | HDAC6抑制剂(HPOB);化合物HPOB;N-羟基-4-(2-((2-羟乙基)(PH苯基)氨基)-2-氧乙基)苯甲酰胺 |
| 英文名称 | HPOB |
| 英文同义词 | HPOB;N-hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide;4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl- benzeneacetamide HPOB;4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide;CS-1829;Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-;HPOB,HDAC6 inhibitor |
| CAS号 | 1429651-50-2 |
| 分子式 | C17H18N2O4 |
| 分子量 | 314.34 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;标准品;Inhibitors |
| Mol文件 | 1429651-50-2.mol |
| 结构式 |  |
HDAC6抑制剂 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：可溶1mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
HPOB是一种有效的，选择性 HDAC6抑制剂，IC50为56 nM，选择性比对其它HDACs高30多倍。In normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells.In mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d i.p.), when in combination with SAHA, causes suppression of the growth of established tumors, while produces no significant suppression when used alone.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-19747 | HPOB | 1429651-50-2 | 5mg | 500元 |
| 2024/01/25 | HY-19747 | HPOB | 1429651-50-2 | 10mM * 1mLin DMSO | 550元 |