氯唑西林钠一水合物
氯唑西林钠一水合物 性质
| 熔点 | 170℃ |
|---|---|
| 沸点 | 689℃ |
| 闪点 | >110°(230°F) |
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | H2O中可溶50mg/mL |
| 形态 | 固体 |
| 颜色 | 白色至橙色再至绿色 |
| 水溶解性 | Soluble in water |
| Merck | 13,2444 |
| BRN | 5403885 |
| CAS 数据库 | 7081-44-9(CAS DataBase Reference) |
Cloxacillin Sodium是Cloxacillin的钠盐形式，是一种耐青霉素酶，耐酸，半合成的青霉素。
Cloxacillin is an antibiotic useful for the study of a number of bacterial infections.
Cell Viability Assay
| Cell Line: | Strains M12 and M60. |
| Concentration: | 0.5 μg/mL. |
| Incubation Time: | 4-24 h. |
| Result: | Significantly reduced the bacterial numbers. |
Cloxacillin sodium (50 mg/kg, Subcutaneously) results a significant antibiotic efficacy against S. aureus .
| Animal Model: | Mice. |
| Dosage: | 10 mg/kg ( Pharmacological Analysis ). |
| Administration: | Given subcutaneously. |
| Result: | Reached a maximal concentration in plasma of 8.4 μg/mL at 10 min and had a half-life of approximately 15 min. |
| Animal Model: | Mice injected with approximately 2 × 10 6 CFU of bacteria in 0.1 mL saline were aseptically injected into the right thigh muscle. |
| Dosage: | 0–500 mg/kg. |
| Administration: | Subcutaneously in the nuchal region at 1 h after infection. |
| Result: | Resulted in a significant decrease in the number of viable S. aureus measured 18 h thereafter. |
化学性质
白色粉末或结晶性粉末。熔点170℃（分解）。易溶于水，溶于乙醇，微溶于氯仿，有引湿性，微臭，味苦。用途
该品为半合成抗菌素，与苯唑西林的作用特点和用途均极相似，对耐药金葡菌该品有杀菌作用。口服或肌注吸收较好，血浓度比苯唑西林高2倍，主要用于耐药金葡菌所致感染，如败血症、骨髓炎、皮肤软组织感染、心内膜炎、泌尿系统感染及脑膜炎等疗效较好。生产方法
邻甲苯胺经重氮化、置换、氯化、水解、肟化等操作。得到邻氯苯甲肟氯，然后与乙酰乙酸乙酯环合、用五氯化磷氯化，得到3-邻氯苯基-5-甲基-4异噁酰氯，最后与6-APA缩合得到邻氯青霉素碱、加异辛酸钠成盐、即为邻氯青霉素钠。安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 36/37/38-42/43 |
| 安全说明 | 26-36 |
| WGK Germany | 2 |
| RTECS号 | XH8920000 |
| 海关编码 | 29411099 |
| 提供商 | 语言 |
|---|---|
|
英文
|
氯唑西林钠一水合物 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B0466 | 氯唑西林钠一水合物 Cloxacillin sodium monohydrate | 7081-44-9 | 100mg | 300元 |
| 2024/01/25 | HY-B0466B | Cloxacillin sodium | 100 mg | 280元 |