N-甲基-D-天冬氨酸
中文名称 | N-甲基-D-天冬氨酸 |
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中文同义词 | N-甲基-D-天冬氨酸水合物;N-甲基-D-天门冬胺基乙酸;N-甲基-D-天(门)冬氨酸;N-甲基-D-天冬氨酸;N-甲基-D-天冬氨酸(NMDA);(R)-2-(甲基氨基)丁二酸;N-甲基-D-天门冬氨酸, ≥97%;N-甲基-D-天门冬氨酸(CAS号:6384-92-5) |
英文名称 | N-Methyl-D-aspartic acid |
英文同义词 | N-ALPHA-METHYL-D-ASPARTIC ACID HYDROCHLORIDE;N-Methyl D-artic acid.;(2R)-2-methylaminobutanedioic acid;(R)-2-(Methylamino)butanedioic acid;N-Methyl-D-Asp-OH;N-Methyl-D-aspartic acid,98%;N-Methyl-D-aspartic acid,(R)-2-(Methylamino)succinic acid, NMDA;N-Methyl-D-aspartic Acid Hydrate |
CAS号 | 6384-92-5 |
分子式 | C5H9NO4 |
分子量 | 147.13 |
EINECS号 | 227-012-0 |
相关类别 | 神经信号;小分子抑制剂,天然产物;氨基酸及其衍生物;保护氨基酸;非天然氨基酸;氨基酸;Glutamate receptor;Glutamate;amino acids;Inhibitors;Pyridines;营养剂;医药原料;原料;试剂盒-细胞分析试剂盒;化工中间体;医药原料 |
Mol文件 | 6384-92-5.mol |
结构式 |
N-甲基-D-天冬氨酸 性质
熔点 | 187-192 °C |
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比旋光度 | -28 º (c=1, HCl 6N) |
沸点 | 267.21°C (rough estimate) |
密度 | 1.4285 (rough estimate) |
折射率 | -15 ° (C=2, H2O) |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 可溶于酸性水溶液(少许)、DMSO(少许)、水(少许) |
形态 | 固体 |
酸度系数(pKa) | 2.21±0.23(Predicted) |
颜色 | 白色 |
水溶解性 | slightly soluble |
敏感性 | Hygroscopic |
Merck | 14,6662 |
BRN | 1724431 |
LogP | 1.390 (est) |
CAS 数据库 | 6384-92-5(CAS DataBase Reference) |
Target | Value |
NMDA receptor |
NMDA是兴奋性氨基酸神经递质,只与NMDA受体结合,而不会影响其他谷氨酸受体(如AMPA和Kainate)。NMDA特异性与NMDA受体的NR2亚基结合,刺激非特异性阳离子通道的打开,使Ca
NMDA (0.2 nM) shows significant effects on MF, IF, IL, and EL, respectively, decreasing the mount and intromission frequencies, and shortening the intromission and ejaculation latencies. NMDA and AP-5 significantly, respectively, facilitates and inhibits the ejaculatory behavior during the copulation testing 30 min. Bilateral microinjection of NMDA into PVN significantly increases the baseline LSNA, the peaking increment of LSNA occurred within 5 min from the time of NMDA microinjected into PVN.
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