雌马酚
中文名称 | 雌马酚 |
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中文同义词 | R,S-雌马酚;)-雌马酚;纳米脂质体雌马酚;(卤)-EQUOL;(+)-雌马酚;雌马酚,(±)-雌马酚;3-(4-羟基苯基)四氢苯并吡喃-7-醇;雌马酚 98% 不是S型,混旋的 |
英文名称 | (+/-)-EQUOL |
英文同义词 | 7,4'-HoMoisoflavane;NV 07α;3-(4-Hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol 7-Hydroxy-3-(4-hydroxyphenyl)chroman 4',7-Isoflavandiol;3,4-Dihydro-3-(4-hydroxyphenyl)-2H-chromen-7-ol, (+/-)-Equol, 4',7-Isoflavandiol, 7-Hydroxy-3-(4-hydroxyphenyl)chroman;4',7-Isoflavandiol, (+/-)-Equol;4′,7-Dihydroxyisoflavane;(+/-)-Equol (GMP);(±)-EQUOL >= 99.0% (TLC) |
CAS号 | 94105-90-5 |
分子式 | C15H14O3 |
分子量 | 242.27 |
EINECS号 | 618-999-2 |
相关类别 | 吡喃;医药原料;功能性食品添加;Metabolites;metabolite;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals |
Mol文件 | 94105-90-5.mol |
结构式 |
雌马酚 性质
熔点 | 158-160?C |
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沸点 | 441.7±45.0 °C(Predicted) |
密度 | 1.286±0.06 g/cm3(Predicted) |
储存条件 | Inert atmosphere,Store in freezer, under -20°C |
溶解度 | 溶于乙醇 |
形态 | 结晶粉末 |
酸度系数(pKa) | 9.94±0.40(Predicted) |
颜色 | 白色至浅黄色至浅红色 |
水溶解性 | Soluble in DMSO and methanol or 100% ethanol. Insoluble in water. |
敏感性 | Hygroscopic |
BRN | 87752 |
InChI | InChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2 |
InChIKey | ADFCQWZHKCXPAJ-UHFFFAOYSA-N |
SMILES | C1OC2=CC(O)=CC=C2CC1C1=CC=C(O)C=C1 |
Equol is first isolated and identified from pregnant-mares' urine and later found in the urine of the goat, cow, hen and sheep. Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers. S-equol is the exclusive product of human intestinal bacterial synthesis from soy isoflavones and both enantiomers are bioavailable. S-equol has a high affinity for estrogen receptor beta (K i =0.73 nM), whereas R-equol is relatively inactive. Equol could promote the proliferation and differentiation of rat osteoblasts through activating the ER-PKCα-related signaling pathway. The alkaline phosphatase activity also increases significantly in all of the equol and 17β-estradiol (E2 ) groups. Equol also significantly elevates the osteocalcin levels.
Equol is a modest natriuretic and vasorelaxant agent in the rat. Orally administered equol is about 8-fold less potent than orally administered furosemide. In isolated aortic rings precontracted by administration of phenylephrine, administration of equol relaxes the contracted aorta (concentration for half-maximal activity 58.9±16 μM). Equol possesses anticancer activity that suppresses tumor formation via apoptosis induction in rats with DMBA-induced mammary gland tumors. In addition, equol shows a hepatic protective effect by acting as an antioxidant and by reducing apoptosis.
安全信息
WGK Germany | 3 |
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海关编码 | 2932990090 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | E0922 | (±)-雌马酚 (±)-Equol | 94105-90-5 | 200mg | 30元 |