桉油烯醇
| 中文名称 | 桉油烯醇 |
|---|---|
| 中文同义词 | 桉油烯醇;桉油烯醇,斯巴醇,油烯醇;匙叶桉油烯醇;油烯醇 |
| 英文名称 | SPATHULENOL |
| 英文同义词 | spathulenol,(+)-spathulenol,espatulenol;SPATHULENOL;[1ar-(1aà,4aà,7á,7aá,7bà)]-Decahydro-1,1,7-trimethyl-4-methylene-1H-cycloprop[e]azulen-7-ol;Spathulel;1H-Cycloprop[e]azulen-7-ol, decahydro-1,1,7-trimethyl-4-methylene-, (1aR,4aR,7S,7aR,7bR)-;(1aR,4aR,7S,7aR,7bR)-1,1,7-Trimethyl-4-methylenedecahydro-1H-cyclopropa[e]azulen-7-ol;(1aR,4aβ,7aα,7bβ)-Decahydro-1,1,7-trimethyl-4-methylene-1H-cycloprop[e]azulen-7α-ol;Espatulenol |
| CAS号 | 6750-60-3 |
| 分子式 | C15H24O |
| 分子量 | 220.35 |
| EINECS号 | |
| 相关类别 | 标准品;植物提取物;中药对照品;对照品;分析试剂标准品;标准品 -对照药材 |
| Mol文件 | 6750-60-3.mol |
| 结构式 |  |
桉油烯醇 性质
| 沸点 | 284.7 °C |
|---|---|
| 密度 | 1.02±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 15.10±0.40(Predicted) |
| 气味 (Odor) | 草本果香味 |
| 香型 | earthy |
| LogP | 4.406 (est) |
桉油烯醇为有机醇化合物，主要用于含量测定，不作其他用途。
桉油烯醇置阴凉干燥处、避光保存。桉油烯醇应在低温下保存，长时间在暴露在空气中，含量会有所降低。Spathulenol 分离自 Psidium guineense Sw，具有抗氧化，抗炎，抗增殖和抗分枝杆菌活性。 Spathulenol 在 DPPH 系统中显示出高抗氧化活性，IC50 为 85.60 μg/mL。Spathulenol exhibits a high antioxidant activity s in the DPPH and MDA system, exhibits significant DPPH free radical activity, with IC 50 values of 85.60 μg/mL [1].
Spathulenol (oral administration; 300 mg/kg) shows a significant inhibition in the Cg-induced mice paw oedema and pleurisy model. In a spontaneous lipoperoxidation rat brain homogenate model, when incubated in controlled temperature and oxygenation conditions, PG-1 exhibits a high activity with an IC 50 value of 26.13 μg/mL, respectively, which is comparable to a commercial antioxidant BHT (38.41 μg/mL), Thus, PG-1 contributes to a decrease in the generation of MDA, which is a toxic product resulting from the degradation of the cell membrane by lipid peroxidation, causing cell ruptures and mutations [1].