醋酸卡贝缩宫素
| 中文名称 | 醋酸卡贝缩宫素 |
|---|---|
| 中文同义词 | 醋酸卡贝缩宫素 37025-55-1;卡贝缩宫素三氟醋酸盐;卡比托辛/卡贝缩宫素;醋酸卡贝缩宫素,卡比托辛;卡贝缩宫素;醋酸卡贝缩宫素;卡比托辛;卡贝缩官素;卡贝缩宫素 |
| 英文名称 | Carbetocin |
| 英文同义词 | Butyryl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2(Disulfide bond);N-(4-Mercapto-1-oxobutyl)-O-methyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamidecyclic (1-5)-thioether acetate;CARBAOXYTOCIN;Carbetocin, (Butyryl1,Tyr(Me)2)-1-Carbaoxytocin;BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDE BOND BETWEEN BUTYRYL-4-YL AND CYS);BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 TRIFLUOROACETATE SALT;(BUTYRYL1,TYR(ME)2)-1-CARBAOXYTOCIN TRIFLUOROACETATE SALT;(BUTYRYL1,TYR(ME)2)-OXYTOCIN |
| CAS号 | 37025-55-1 |
| 分子式 | C45H69N11O12S |
| 分子量 | 988.17 |
| EINECS号 | 253-312-6 |
| 相关类别 | 原料药（API）;多肽;医药原料药;医用原料;多肽原料药;生物制药;原料药;医药原料药 科研原料;Peptide;Vasopressin and Oxytocin receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs;医药原料;药物多肽;杂质对照品;肽类;标准品;生物化工;化学产品 |
| Mol文件 | 37025-55-1.mol |
| 结构式 |  |
醋酸卡贝缩宫素 性质
| 熔点 | 140 - 160°C |
|---|---|
| 沸点 | 1477.9±65.0 °C(Predicted) |
| 比旋光度 | D -69.0° (c = 0.25 in 1M acetic acid) |
| 密度 | 1.218±0.06 g/cm3(Predicted) |
| 储存条件 | -15°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.07±0.70(Predicted) |
| 颜色 | 白色至米色 |
| 水溶解性 | Soluble to 29.65 mg/ml in water |
| 稳定性 | 吸湿性 |
| InChIKey | NSTRIRCPWQHTIA-FOILTOEQNA-N |
Carbetocin is an agonist with about 10-fold lower affinity for the oxytocin receptor but with significantly higher stability and a longer duration of action. Carbetocin has higher affinity to the chimeric E1 receptor and especially to each of the combinations of E1 with the other extracellular domains, i.e. chimeric receptors E13 (K
i
=13 nM), E123 (K
i
=56 nM), and E1234 (K
i
=37 nM).
Carbetocin (2-20 mg/kg; i.p.) has a significant effect of treatment on the percent time spent climbing, swimming and immobile.
Carbetocin (1, 10,100 μg/rat, i.c.v.) reveals a dose-dependent increase in the percent time spent swimming and a corresponding reduction in immobility following acute administration of 100 μg/rat.
| Animal Model: | Male Sprague-Dawley rats weighing between 300 and 500 g |
| Dosage: | 2, 6.4, 20 mg/kg |
| Administration: | IP; single dose |
| Result: | Increased climbing with 6.4 mg/kg and resulted in a significantly greater proportion of time spent swimming with 20 mg/kg. |
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-17573A | Carbetocin acetate | 1 mg | 200元 | |
| 2024/01/25 | HY-17573A | 醋酸卡贝缩宫素 Carbetocin acetate | 37025-55-1 | 5mg | 500元 |