美拉诺坦 II
| 中文名称 | 美拉诺坦 II |
|---|---|
| 中文同义词 | 美拉诺坦 II;醋酸美拉诺坦醋酸;醋酸美拉诺坦II;醋酸美拉诺坦2;美拉诺坦2;美那诺坦II;美黑素;醋酸美拉诺坦Ⅱ MELANOTANII ACETATE(MT-2) |
| 英文名称 | Melanotan II |
| 英文同义词 | Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) aMide Melanotan II, MTII, BreMelanotide aMide;AC-NLE-CYCLO(-BETA-ASP-HIS-D-PHE-ARG-TRP-EPSILON-LYS-NH2);AC-NLE-CYCLO(-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2) ACETATE SALT;AC-NLE4-C[ASP5, D-PHE7, LYS10]ALPHA-MSH (4-10)-NH2;AC-[NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10)-NH2;(AC-NLE4, ASP5, DPHE7, LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE;AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2;(1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-10-(benzyl)-7-(3-guanidinopropyl)-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaketo-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide |
| CAS号 | 121062-08-6 |
| 分子式 | C50H69N15O9 |
| 分子量 | 1024.18 |
| EINECS号 | 1308068-626-2 |
| 相关类别 | 保护氨基酸;多肽;多肽中间体;医药原料;医药原料药;肽;细胞信号和神经生物学;信号转导通路激酶抑制剂;细胞生物学;化工原料-材料辅剂;原料药;医用原料;生化试剂-蛋白质;生物化工-氨基酸及氨基酸衍生物;药物肽;武汉贝尔卡主打;化学试剂;定制多肽;细胞-细胞系;试剂盒-Elisa试剂盒;标准品;Amino Acid Derivatives;Peptide;Melanocortin receptor;Peptides;黄金产品;药物多肽 |
| Mol文件 | 121062-08-6.mol |
| 结构式 |  |
美拉诺坦 II 性质
| 密度 | 1.43 |
|---|---|
| RTECS号 | OL4225000 |
| 储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | H2O: 5 mg/mL, 可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.00±0.70(Predicted) |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 0.70 mg/ml in water |
| InChIKey | JDKLPDJLXHXHNV-MFVUMRCOSA-N |
| CAS 数据库 | 121062-08-6(CAS DataBase Reference) |
美拉诺坦 II 是一种实验室制造的化学物质，与人体内的激素相似。美拉诺坦 II 已被证明对人类具有黑色素生成（鞣制）和壮阳作用。
Melanotan (MT)-II是一种合成的黑皮质素 (melanocortin) 受体激动剂。它是可注射用的多肽荷尔蒙，可促进晒黑。
Melanotan (MT)-II is a potent non-selective melanocortin receptor agonist with high affinity for MC1, MC3, MC4, and MC5 receptor subtypes which are involved in the regulation of a number of physiological systems such as the pigmentary system, energy homoeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system.
Melanotan (MT)-II exerts a dose-dependent inducer activity on erection by eliciting erectile events and shortening latency of the first erectile event to occur. Erectile responses elicited by cavernous nerve stimulation are increased after i.v. melanotan (MT)-II (1 mg/kg), thereby exerting facilitator effect on erection. Melanotan (MT)-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Melanotan (MT)-II significantly enhances the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 μg/kg per 48 h, s.c., but not at a dose of 2 or 50 μg/kg. Melanotan (MT)-II is a potent initiator of penile erection in men with erectile dysfunction. Melanotan (MT)-II reduces food intake and body weight and invokes thermogenic responses in a mouse model.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%