佐剂肽
| 中文名称 | 佐剂肽 |
|---|---|
| 中文同义词 | 胞壁酰二肽;N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺水合物;N-乙酰胞壁酰-L-丙-D-异谷氨酰胺水合物;佐剂肽;N-乙酰胞壁酰基-L-丙氨酰基-D-异谷氨酰胺 水合物;胞壁酰二肽(佐剂肽);MURAMYL DIPEPTIDE,佐剂肽;胞壁酰二肽MDP |
| 英文名称 | Muramyl Dipeptide |
| 英文同义词 | acetylmuramyl-alanyl-isoglutamine;n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamin;n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamine;N-AC-MURAMYL-ALA-D-GLU-NH2;N-AC-MURAMYL-ALA-D-GLU-NH2 2H2O;N-ACETYL-MURAMYL-L-ALA-D-ISOGLN;N-ACETYLMURAMYL-L-ALA-D-ISOGLUTAMINE;N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE |
| CAS号 | 53678-77-6 |
| 分子式 | C19H32N4O11 |
| 分子量 | 492.48 |
| EINECS号 | 258-696-9 |
| 相关类别 | 精细化工;原料 |
| Mol文件 | 53678-77-6.mol |
| 结构式 |  |
佐剂肽 性质
| 比旋光度 | D25 +44° (acetic acid) |
|---|---|
| 沸点 | 1071.8±65.0 °C(Predicted) |
| 密度 | 1.390±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | H2O：10 mg/mL，澄清，无色 |
| 酸度系数(pKa) | 4.44±0.10(Predicted) |
| 形态 | 缓冲水溶液 |
| Merck | 13,6329 |
| BRN | 4220745 |
| CAS 数据库 | 53678-77-6(CAS DataBase Reference) |
佐剂肽是指一种通过诱发、加强和/或促进针对抗原的免疫反应来促进或调节抗原功能而作为功能性组分(组合物中)的肽。佐剂肽主要用于医药、化工领域。Muramyl dipeptide (MDP) 是肽聚糖的共有结构单元。Muramyl dipeptide 通过诱导 Runx2 来诱导 bone formation。
| Target | Value |
|
Runx2
() |
Muramyl dipeptide (0.1-10 µg/mL; 24 hours) increases protein expression of Runx2 in a dose-dependent manner.
Muramyl dipeptide (0.1-10 µg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner.
Western Blot Analysis
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.1, 1, 10 µg/mL |
| Incubation Time: | 24 hours |
| Result: | Increased protein expression of Runx2 in a dose-dependent manner. |
RT-PCR
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.1, 1, 10 µg/mL |
| Incubation Time: | 6 hours |
| Result: | Increases mRNA levels of Runx2 in a dose-dependent manner. |
Muramyl dipeptide (1.25 mg/kg; i.p.; twice) alleviates bone loss induced by osteoporosis.
| Animal Model: | RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice) |
| Dosage: | 1.25 mg/kg |
| Administration: | i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks) |
| Result: | Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N). |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-127090 | 佐剂肽 Muramyl dipeptide | 53678-77-6 | 1mg | 914元 |
| 2024/01/25 | HY-127090 | 佐剂肽 Muramyl dipeptide | 53678-77-6 | 5mg | 2400元 |