ALSTONINE
| 中文名称 | ALSTONINE |
|---|---|
| 中文同义词 | 鸭脚木碱,鸡骨常山碱 |
| 英文名称 | Indole alkaloid |
| 英文同义词 | Aids002662;Aids-002662;3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium;Oxayohimbanium,3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, inner salt, (19a,20a)- |
| CAS号 | 642-18-2 |
| 分子式 | C21H20N2O3 |
| 分子量 | 348.4 |
| EINECS号 | |
| 相关类别 | 生物碱;标准品 -中药标准品 |
| Mol文件 | 642-18-2.mol |
| 结构式 |  |
ALSTONINE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues.
In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg.
Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages.
Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells.