5-脱氧-5-甲硫腺苷
| 中文名称 | 5-脱氧-5-甲硫腺苷 |
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| 中文同义词 | 5'-脱氧-5'-硫代甲基酰苷;5-脱氧-5-甲硫腺苷;5ˊ-脱氧-5ˊ-甲硫基腺苷;甲硫腺苷;5-脱氧-5-甲硫腺苷 (5'-脱氧-5'-硫代甲基酰苷、5ˊ-脱氧-5ˊ-甲硫基腺苷);5'-甲硫腺苷;5′-脱氧-5′-腺苷;甲硫腺苷对照品 |
| 英文名称 | 5'-DEOXY-5'-METHYLTHIOADENOSINE |
| 英文同义词 | 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol;7-(5-Methylthio-5-deoxy-D-ribofuranosyl)-7H-purine-6-amine;7-[Tetrahydro-3α,4α-dihydroxy-5β-(methylthiomethyl)furan-2-yl]-7H-purin-6-amine;5'-S-Methyl-5'-thioadesine;5'-Deoxy-5'-(methylthio)adenosine ,98%;1-(6-AMino-9H-purin;5'-Deoxy(Methylthio)adenosine;NSC 335422 |
| CAS号 | 2457-80-9 |
| 分子式 | C11H15N5O3S |
| 分子量 | 297.33 |
| EINECS号 | |
| 相关类别 | 中药对照品;生物碱;化工原料;Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides |
| Mol文件 | 2457-80-9.mol |
| 结构式 |  |
5-脱氧-5-甲硫腺苷 性质
| 熔点 | 210-213 °C (dec.) |
|---|---|
| 沸点 | 642.7±65.0 °C(Predicted) |
| 密度 | 1.85±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMF（少量）、DMSO（少量）、甲醇（少量） |
| 酸度系数(pKa) | 13.10±0.70(Predicted) |
| 形态 | 白色固体 |
| 颜色 | 白色至类白色 |
| BRN | 42420 |
5-脱氧-5-甲硫腺苷是一种C-5' 的羟基被甲硫基（甲硫基）取代的腺苷，可用作抑制剂。5'-Methylthioadenosine 是由 S-腺苷酸产生的，有强效的抑制作用。
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Human Endogenous Metabolite
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5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration [1] .
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英文
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