土霉素二水合物
中文名称 | 土霉素二水合物 |
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中文同义词 | 氧四环素/土霉素 二水合物;二水合土霉素;4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氢-3,5,6,10,12,12a-六羟基-6-甲基-1,11-二氧代-并四苯-2-甲酰胺二水合物;土霉素/ 强力霉素;土霉素注射液;二水土霉素;地霉素;土霉素二水合物 |
英文名称 | Oxytetracycline dihydrate |
英文同义词 | OXYTETRACYCLINE DIHYDRATE;4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide dihydrate;DOXYCYCLINE USP 23;OXYCYCLINE;DOXYCYCLINE HYCHLATE;DOXYCYCLINE HCL ( VETERINARY);OXYTETRACYCLINE HCL BP;DOXYCYCLINE HYDRATE BP98 USP23 |
CAS号 | 6153-64-6 |
分子式 | C22H26N2O10 |
分子量 | 478.45 |
EINECS号 | 612-168-8 |
相关类别 | 小分子抑制剂,天然产物;成药;生化试剂;抗生素;原料药;原料中间体-原料药;医药、农药及染料中间体;添加剂;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;EUTONYL;有机化工原料;医药原料;兽用原料;对照品;FINISHED MEDICINE;Interferes with Protein SynthesisSpectrum of Activity;L - ZAntibiotics;Mechanism of Action;Tetracyclines;Inhibitors |
Mol文件 | 6153-64-6.mol |
结构式 |
土霉素二水合物 性质
熔点 | 181-182 °C |
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比旋光度 | -216 º (c=1,0.1 M HCl) |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 1M HCl:0.1 M 黄色至橙黄色,透明 |
形态 | 结晶 |
颜色 | 粘黄色 |
水溶解性 | slightly soluble |
CAS 数据库 | 6153-64-6(CAS DataBase Reference) |
EPA化学物质信息 | Oxytetracycline dihydrate (6153-64-6) |
HSV-1
|
Bacterial
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Human Endogenous Metabolite
|
Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.
The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in
Morone chrysops x M. saxatilis
, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.
安全信息
危险品标志 | Xn,Xi |
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危险类别码 | 63-36-36/37/38 |
安全说明 | 22-24/25-36/37/39-26-36 |
WGK Germany | 3 |
海关编码 | 29413000 |
提供商 | 语言 |
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英文
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英文
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