双羟萘酸噻嘧啶
| 中文名称 | 双羟萘酸噻嘧啶 |
|---|---|
| 中文同义词 | 含 4,4′-亚甲基双(3-羟基-2-萘甲酸) 的 1-甲基-2-(2-[2-噻吩基]乙烯基)-1,4,5,6-四氢嘧啶化合物;恩波酸噻嘧啶;抗虫灵;双羟萘酸噻嘧啶(噻嘧啶);双羟萘酸噻嘧啶;双羟萘酸喹嘧啶;(E)-1-甲基-2-[2-(2-噻吩基)乙烯基]-1,4,5,6-四氢嘧啶 4,4'-亚甲基-双(3-羟基2-奈酸)盐;双羟萘酸噻嘧啶/(E)-1-甲基-2-[2-(2-噻吩基)乙烯基]-1,4,5,6-四氢嘧啶 4,4'-亚甲基-双(3-羟基2-奈酸)盐 |
| 英文名称 | Pyrantel pamoate |
| 英文同义词 | Pyrantel pamoate,1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine compound with 4,4′-methylenebis(3-hydroxy-2-naphthoic acid);1,4,5,6-Tetrahydro-1-Methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyriMidine 4,4'-Methylenebis[3-hydroxy-2-naphthalenecarboxylate];4,4'-Methylenebis[3-hydroxy-2-naphthalenecarboxylic Acid coMpound with 1,4,5,6-Tetrahydro-1-Methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyriMidine;Early Bird;HelMintox;NeMocid;Piranver;Pyrantel paMoate bioxtra |
| CAS号 | 22204-24-6 |
| 分子式 | C34H30N2O6S |
| 分子量 | 594.68 |
| EINECS号 | 244-837-1 |
| 相关类别 | 原料;小分子抑制剂;医药原料药;中间体;抗生素;原料药;抗寄生虫病药;驱肠虫药;医药原料;医药化工类;医用原料;化工原料;原料中间体-原料药;化工原料;医用原料;Veterinaries;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;NEMEX;化学试剂;有机中间体;抗寄生虫;试剂;22204-24-6;化学原料;兽用试剂原料 |
| Mol文件 | 22204-24-6.mol |
| 结构式 |  |
双羟萘酸噻嘧啶 性质
| 熔点 | 266-267°C |
|---|---|
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 几乎不溶于水，溶于二甲基亚砜，几乎不溶于甲醇。 |
| 形态 | 粉末 |
| 颜色 | 粘黄色 |
| 水溶解性 | <0.1 g/100 mL at 19 ºC |
| BRN | 9034755 |
| BCS Class | 4 |
| InChIKey | AQXXZDYPVDOQEE-MXDQRGINSA-N |
| SMILES | C(C1=C(C(C(=O)O)=CC2=CC=CC=C12)O)C1=C(C(C(=O)O)=CC2=CC=CC=C12)O.C(/C1=NCCCN1C)=C\C1SC=CC=1 |
| EPA化学物质信息 | 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1) (22204-24-6) |
Pyrantel pamoate (Pyrantel Embonate)是一种广谱驱虫剂，用于治疗一些寄生虫感染。
Pyrantel induces
Ascaris suum
muscle contraction, with a pEC
50
of 7.24.
Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle.
Pyrantel (72 h) inhibits the survival of
Ancylostoma ceylanicum
,
Necator americanus
and
Trichuris muris
on the third-stage larvae (IC
50
s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC
50
s=>100, 7.6, and 34.1 µg/mL, respectively).
Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.
化学性质
黄色至褐色晶体粉末安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | QL2287000 |
| 海关编码 | 2934990002 |
| 提供商 | 语言 |
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英文
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英文
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双羟萘酸噻嘧啶 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-12640 | 双羟萘酸噻嘧啶 Pyrantel pamoate | 22204-24-6 | 100mg | 200元 |
| 2024/01/25 | HY-12640 | 双羟萘酸噻嘧啶 Pyrantel pamoate | 22204-24-6 | 10mM * 1mLin DMSO | 220元 |