醉茄素 A
中文名称 | 醉茄素 A |
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中文同义词 | 醉茄素 A,来源于睡茄叶;霜抑素A;WITHAFERIN A STANDARD;WITHAFERIN A BIOCHEMICA |
英文名称 | WITHAFERIN A |
英文同义词 | WITHAFERIN A;5,6-beta-epoxy-4-beta,22,27-trihydroxy-1-5-beta-ergosta-24-dien-26-oicacid;delta-lactone,(20s,22r)-oxo;nsc-101088;(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone;NSC 273757;Withaferine;(20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta- 2,24-dien-26-oic Acid δ-Lactone |
CAS号 | 5119-48-2 |
分子式 | C28H38O6 |
分子量 | 470.6 |
EINECS号 | 999-999-2 |
相关类别 | 合成;分析试剂标准品;中药对照品;生化试剂;新品;对照品;标准品,对照品;化工原料;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;antibiotic;标准品-对照品 |
Mol文件 | 5119-48-2.mol |
结构式 |
醉茄素 A 性质
熔点 | 252-253℃ |
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比旋光度 | D28 +125° (c = 1.30 in CHCl3) |
沸点 | 680.7±55.0 °C(Predicted) |
密度 | 1.28 |
闪点 | 226℃ |
储存条件 | Desiccate at -20°C |
溶解度 | 可溶于 DMSO(高达 20 mg/ml) |
酸度系数(pKa) | 13.49±0.70(Predicted) |
形态 | 白色固体 |
颜色 | 白色 |
稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
InChIKey | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
Target | Value |
NF-κB
() | |
vimentin
() |
Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs).
Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice.
安全信息
危险品标志 | T |
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WGK Germany | 3 |
RTECS号 | KE7288500 |
海关编码 | 29322090 |