粉蝶霉素A
中文名称 | 粉蝶霉素A |
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中文同义词 | 抗生素;粉蝶霉素A;杀粉蝶菌素A;菜青素A;杀粉蝶菌素;2-((2E,5E,7E,9R,10R,11E)-10-羟基-3,7,9,11-四甲基十三烷-2,5,7,11-四烯-1-基)-5,6-二甲氧基-3-甲基吡啶-4-醇 |
英文名称 | PIERICIDIN A |
英文同义词 | ,5,7,11-tetramethyl-,(all-e)-(4s,5s)-;2,6,9,11-tridecatetraen-4-ol,13-(4-hydroxy-5,6-dimethoxy-3-methyl-2-pyridyl)-3;piericidin;piericidin(sub1);piericidinea;SN 198E;SHAOGUAMYCIN B;SHAOGUANMYCIN B |
CAS号 | 2738-64-9 |
分子式 | C25H37NO4 |
分子量 | 415.57 |
EINECS号 | |
相关类别 | 微生物代谢物;试剂盒-细胞分析试剂盒;小分子;Antibiotic |
Mol文件 | 2738-64-9.mol |
结构式 |
粉蝶霉素A 性质
沸点 | 614.9±55.0 °C(Predicted) |
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密度 | 1.044±0.06 g/cm3(Predicted) |
闪点 | 85 °C |
储存条件 | 2-8°C |
溶解度 | 可溶于DMSO(高达25mg/ml)或乙醇(高达20mg/ml)。 |
酸度系数(pKa) | 5.21±0.33(Predicted) |
形态 | 液体 |
颜色 | 黄绿色 |
稳定性 | 自购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 1 个月。 |
In a cell free assay, the potency of Piericidin A to inhibit mitochondrial complex I is ∼2 fold smaller than the one of annonacin. In cultured neurons, Piericidin A potently induces the redistribution of phosphorylated tau from the dendrites into the cell soma and induces cell death.
The viability of Tn5B1-4 cells is inhibited by Piericidin A in a time- and concentration-dependent manner with IC
50
value of 0.061 μM, whilst Piericidin A shows slight inhibitory effect on the viability of HepG2 and Hek293 cells with IC
50
value of 233.97 μM and 228.96 μM, respectively. Piericidin A induces apoptosis of Tn5B1-4 cells coincides with a decrease in the mitochondrial membrane potential.
Piericidin A (0.5 mg/kg/d; for 28 days via osmotic minipumps) significantly increases the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S +/+ mice. Piericidin A leads to increased levels of pathologically phosphorylated tau only in P301S +/+ mice. The synaptic density is reduced by Piericidin A treatment in P301S +/+ mice. Exposure to Piericidin A aggravates the course of genetically determined tau pathology.
安全信息
危险品标志 | T+,Xn |
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危险类别码 | 26/27/28-20/21/22 |
安全说明 | 28-36/37-45 |
危险品运输编号 | UN 3382 6.1/PG 1 |
WGK Germany | 3 |
RTECS号 | YD4588000 |
F | 3-10 |
海关编码 | 2933399990 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-114936 | 粉蝶霉素A Piericidin A | 2738-64-9 | 1mg(12.03mM * 200μL in Ethanol) | 4500元 |