匹美诺芬
中文名称 | 匹美诺芬 |
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中文同义词 | 匹美诺芬;匹美诺分;布洛芬吡甲酯;布洛芬吡啶甲醇;2-(4-异丁基苯基)丙酸2-吡啶基甲基酯;布洛芬甲酯对照品;匹美诺酚;布洛芬杂质55 |
英文名称 | Ibuprofen Piconol |
英文同义词 | 2-pyridylmethyl 2-(4-isobutylphenyl)propionate;Ibuprofenpiconol;BE 100;Pimeprofen;Staderm;U 75630;Vesicum;2-(p-Isobutylphenyl)propionic acid 2-pyridylmethyl ester |
CAS号 | 64622-45-3 |
分子式 | C19H23NO2 |
分子量 | 297.4 |
EINECS号 | 264-979-8 |
相关类别 | 化学试剂 |
Mol文件 | 64622-45-3.mol |
结构式 |
匹美诺芬 性质
沸点 | 438.9°C (rough estimate) |
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密度 | 1.0971 (rough estimate) |
折射率 | 1.5000 (estimate) |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 丙酮(微溶)、氯仿(微溶)、甲醇(微溶) |
形态 | 油状 |
酸度系数(pKa) | 3.36±0.12(Predicted) |
颜色 | 无色 |
Ibuprofen piconol is a chemically stable, slightly hygroscopic liquid that strongly partitions into the oil phase and shows no indication of surface activity. This drug has very limited solubility in water (16.5 ppm), modest solubility in glycerol (16.4 mg/mL), and is miscible with less polar organics except for silicone fluids. Varying the initial concentration of ibuprofen piconol does not alter the hydrolysis half-life (concentration range from 50 to 200 μg/mL). The anticoagulant used alters the hydrolysis half-life. For plasma, the half-life is shortest when no anticoagulant is present (t 1/2 =2.5 h) and longer with the presence of anticoagulants; t 1/2 =8.0 h for citrate, t 1/2 =15.5 h for heparin and t 1/2 =161.8 h for EDTA. Red blood cell uptake of ibuprofen piconol is minimal and ranges from 0.4 to 4.1% over the ibuprofen piconol concentrations used in the study.
When ibuprofen piconol is applied topically, only ibuprofen and its metabolites are observed in plasma and urine. The conversion of ibuprofen piconol to ibuprofen appears to be extremely rapid in vivo .
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101482 | 匹美诺芬 Ibuprofen piconol | 64622-45-3 | 50mg | 350元 |
2024/08/19 | HY-101482 | 匹美诺芬 Ibuprofen piconol | 64622-45-3 | 10mM * 1mLin DMSO | 385元 |