1,8-Diazaspiro[4.5]decane,3-broMo-1,8-bis(phenylMethyl)- synthesis

Yield:1100748-76-2 90%

Reaction Conditions:

Stage #1: 4-allyl-N,1-dibenzylpiperidin-4-aminewith methanol;Acetyl bromide at 0;
Stage #2: with bromine in methanol;dichloromethane at -78;
Stage #3: with potassium carbonate in methanol;dichloromethane;water at 0 - 20; for 16 h;

References:

Jenkins, Ian D.;Lacrampe, Fabienne;Ripper, Justin;Alcaraz, Lilian;Van Le, Phuc;Nikolakopoulos, George;De Leone, Priscila Almeida;White, Rodney H.;Quinn, Ronald J. [Journal of Organic Chemistry,2009,vol. 74,# 3,p. 1304 - 1313] Location in patent:experimental part