(3S-CIS)-(+)-2,3-DIHYDRO-3-ISOPROPYL-7A-METHYLPYRROLO[2,1-B] OXAZOL-5(7A H)-ONE synthesis
- Product Name:(3S-CIS)-(+)-2,3-DIHYDRO-3-ISOPROPYL-7A-METHYLPYRROLO[2,1-B] OXAZOL-5(7A H)-ONE
- CAS Number:116910-11-3
- Molecular formula:C10H15NO2
- Molecular Weight:181.23
98203-44-2
14 suppliers
$505.60/5MG
116910-11-3
10 suppliers
$1975.05/10G
Yield:116910-11-3 68%
Reaction Conditions:
Stage #1: (3S,7aR)-3-isopropyl-7a-methyltetrahydropyrrolo[2,1-b][1,3]-oxazol-5-onewith n-butyllithium;lithium diisopropyl amide in tetrahydrofuran;hexane at -78; for 2 h;Inert atmosphere;
Stage #2: with Phenylselenyl bromide in tetrahydrofuran;hexane at -78 - 20;Inert atmosphere;
Stage #3: with pyridine;dihydrogen peroxide in dichloromethane at 0; for 3 h;Inert atmosphere;enantioselective reaction;
References:
Barra, Lena;Dickschat, Jeroen S. [European Journal of Organic Chemistry,2017,vol. 2017,# 31,p. 4566 - 4571]
2026-48-4
424 suppliers
$16.60/5G
123-76-2
458 suppliers
$5.00/25g
116910-11-3
10 suppliers
$1975.05/10G