Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride synthesis
- Product Name:Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride
- CAS Number:176523-95-8
- Molecular formula:C9H18ClNO2
- Molecular Weight:207.6977
278789-43-8
176523-95-8
General procedure for the synthesis of ethyl 3-methylpiperidine-3-carboxylate hydrochloride from ethyl 1-Boc-3-methylpiperidine-3-carboxylate: 24.2 g (84.8 mmol) of 1-tert-butyl 3-ethyl 3-methylpiperidine-1,3-dicarboxylate was added to 50 mL of ethyl acetate solution of 2.5 M hydrochloric acid. The reaction mixture was stirred at 20°C for 3 hours, then 100 mL of diethyl ether was added. The precipitated crystals were filtered and washed with diethyl ether to give 16.28 g (97% yield) of ethyl 3-methylpiperidine-3-carboxylate hydrochloride.
278789-43-8
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176523-95-8
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Yield:176523-95-8 97%
Reaction Conditions:
with hydrogenchloride in ethyl acetate at 20; for 3 h;
Steps:
b h) Ethyl 3-rn ethylpi pen dine-3 -carboxyl ate
To a solution of 50 ml of 2.5 M hydrochloric acid in ethyl acetate 24.2 g (84.8 rnmol) of Iferf-butyi 3-ethyl 3-methyipiperidine-i,3-dicarboxyiate was added. The reaction mixture was stirred for 3 h at 20 °C, then 100 rnL of diethyl ether was added. The precipitated crystals werefiltered off, washed with diethyl ether to yield 16.28 g (97 %) of the title compound.
References:
WO2018/167630,2018,A1 Location in patent:Page/Page column 29