Phenol, 6-bromo-2,3-dichloro- synthesis

Yield:-

Reaction Conditions:

with bromine in dichloromethane at 0 - 20;

Steps:

5p.A 4-Brorno-2, 3-dichioro-phenol

1.63 g 2,3-diehiorophenol (10.0 mmol) was dissolved in 30 mL DCM and was cooled to0°C. Then 512 pE bromine (10.0 nunol) was added and the mixture was allowed to warm up to room temperature and the mixture was stirred at room temperature overnight. Then it was washed with saturated Na2S2O3 solution, dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified via flash chromatography usingheptane and EtOAc as eluents to obtain a mixture of 6-bromo-2,3-dichloro-phenol and 4- bromo-2,3 -dichloro-phenol.MS (M-H): 239.0.

References:

WO2015/97123,2015,A1 Location in patent:Page/Page column 86