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Technical Data Sheet Crizotinib
Compound Information
Product Name:
Crizotinib
CAS No.:
877399-52-5
Molecular Formula:
C21H22Cl2FN5O
Molecular Weight:
450.34
Storage:
Store at +4°C
Revision Date:
2026-04-27
Analytical Information
| Tests | Specifications |
|---|---|
| Description | Crizotinib (PF-02341066) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively. |
| IUPAC Name | 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Form | powder |
| Color | white to tan |
| Solubility | Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming) |
| HPLC | Shows 99.8% purity |
| NMR | Pass test |
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