| Identification | Back Directory | [Name]
Dabigatran Acyl-β-D-Glucuronide | [CAS]
1015167-40-4 | [Synonyms]
Dabigatran Acyl Glucuronide
Dabigatran Acyl-β-D-Glucuronide
Dabigatran Acyl-β-D-Glucuronide
Dabigatran β-Acyl Glucuronide D4
Dabigatran Acyl-Beta-D-Glucuronide
Dabigatran Acyl-?-D-Glucuronide TFA Salt
Dabigatran Acyl-?-D-Glucuronide-D3 TFA Salt
Dabigatran Acyl--D- glucuronide trifluroacetic acid
Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt
Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt (80%)
N-[[2-[[[4-(AMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine β-D-Glucopyranuronosyl Ester
N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine beta-D-glucopyranuronosyl ester
Dabigatran Acyl--D-glucuronide D3 trifluoroacetate saltQ: What is
Dabigatran Acyl--D-glucuronide D3 trifluoroacetate salt Q: What is the CAS Number of
Dabigatran Acyl--D-glucuronide D3 trifluoroacetate salt Q: What is the storage condition of
Dabigatran Acyl--D-glucuronide D3 trifluoroacetate salt Q: What are the applications of
Dabigatran Acyl--D-glucuronide D3 trifluoroacetate salt | [Molecular Formula]
C31H33N7O9 | [MDL Number]
MFCD21363575 | [MOL File]
1015167-40-4.mol | [Molecular Weight]
647.635 |
| Chemical Properties | Back Directory | [Melting point ]
>155°C (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated), Water | [form ]
Solid | [color ]
Off-White to Light Brown | [Stability:]
Hygroscopic, Unstable in Solution |
| Hazard Information | Back Directory | [Description]
Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran. | [Uses]
A metabolite of Dabigatran. | [Uses]
Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt is a major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers). | [Uses]
The major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. ?NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers). | [storage]
Store at -20°C |
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