| Identification | Back Directory | [Name]
6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine | [CAS]
1042224-63-4 | [Synonyms]
6-imidazo[1
IRAK inhibitor
IRAK inhibitor 1
Cyclopamine inhibitor 1
2-a]pyridin-3-yl-N-4-piperidinyl-
6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl- | [Molecular Formula]
C17H19N5 | [MDL Number]
MFCD22124480 | [MOL File]
1042224-63-4.mol | [Molecular Weight]
293.366 |
| Chemical Properties | Back Directory | [density ]
1.32 | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥14.4 mg/mL in DMSO | [form ]
Powder | [pka]
9.94±0.10(Predicted) |
| Hazard Information | Back Directory | [Biological Activity]
the interleukin-1 receptor associated kinase (irak) family is comprised of four family members irak-1, irak-2, irak-3/m, and irak-4. upon activation of their upstream cognate receptors, irak-4 is thought to phosphorylate irak-1 resulting in the activation and autophosphorylation of irak-1 an subsequent phosphorylation of downstream substrates. irak inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (irak-4). | [in vitro]
the regioisomeric pyridines irak inhibitor 1 (6) and it analogue (7) showed contrasting sar, with the 2,6-pyridine isomer irak inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. at 10 μm, irak inhibitor 1 was found to have 39% inhibition for jnk-1 and 15% inhibition for jnk-2, respectivley [1]. | [target]
IRAK-4 | [IC 50]
35 nm for irak-4 | [References]
[1] buckley gm, ceska ta, fraser jl, gowers l, groom cr, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v. irak-4 inhibitors. part ii: a structure-based assessment of imidazo[1,2-a]pyridine binding. bioorg med chem lett. 2008;18(11):3291-5. |
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www.spiropharma.com.cn |
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Musechem
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www.musechem.com |
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Twochem Co.Ltd.
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