ChemicalBook--->CAS DataBase List--->105955-11-1

105955-11-1

105955-11-1 Structure

105955-11-1 Structure
IdentificationBack Directory
[Name]

OLDA
[CAS]

105955-11-1
[Synonyms]

ODA
OLDA
N-OLEOYLDOPAMINE
N-Oleoyldopamine (OLDA)
N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]9Z-OCTADECENAMIDE
(Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide
(9Z)-N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]-9-OCTADECENAMIDE
9-Octadecenamide, N-[2-(3,4-dihydroxyphenyl)ethyl]-, (9Z)-
[Molecular Formula]

C26H43NO3
[MDL Number]

MFCD05665144
[MOL File]

105955-11-1.mol
[Molecular Weight]

417.62
Chemical PropertiesBack Directory
[Melting point ]

60-61oC
[storage temp. ]

−20°C
[solubility ]

DMSO: ~20 mg/mL, soluble
[form ]

powder
[color ]

white
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

N-Oleoyldopamine is a bioactive lipid found in the mammalian brain that selectively activates the transient receptor potential vanilloid type 1 (TRPV1) channel. It is also a 5-lipoxygenase inhibitor.
[Definition]

ChEBI: N-oleoyldopamine is a fatty amide resulting from the formal condensation of the carboxy group of oleic acid with the amino group of dopamine. Synthesised in catecholaminergic neurons, it crosses the blood-brain barrier and might be considered as a carrier of dopamine into the brain. It is a transient receptor potential vanilloid type 1 (TRPV1) receptor agonist. It has a role as a TRPV1 agonist. It is a fatty amide, a secondary carboxamide, a member of catechols and a N-(fatty acyl)-dopamine. It is functionally related to a dopamine and an oleic acid.
[Biological Activity]

Potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC 50 = 36 nM at hVR1) with low affinity for rCB 1 receptors (K i = 1.6 μ M). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo .
[storage]

Desiccate at -20°C
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