| Identification | More | [Name]
P-XYLENE | [CAS]
106-42-3 | [Synonyms]
1,4-DIMETHYLBENZENE
1，4-Xylene p-Xylene
'LGC' (2031)
PARA-XYLENE
P-XYLENE
1,4-dimethyl-benzen
1,4-Xylene
4-Methyltoluene
4-xylene
ai3-52255
Benzene, 1,4-dimethyl-
Benzene,1,4-dimethyl-
p-Dimethylbenzene
p-Methyltoluene
p-Xylol
Scintillar
xylene(non-specificname)
P-XYLENE, STANDARD FOR GC
P-XYLENE, 99+%, HPLC GRADE
P-XYLENE, ANHYDROUS, 99+% | [EINECS(EC#)]
203-396-5 | [Molecular Formula]
C8H10 | [MDL Number]
MFCD00008556 | [Molecular Weight]
106.17 | [MOL File]
106-42-3.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Melting point ]
12-13 °C (lit.) | [Boiling point ]
138 °C (lit.) | [density ]
0.861 g/mL at 20 °C(lit.)
| [vapor density ]
3.7 (vs air)
| [vapor pressure ]
9 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.495(lit.)
| [Fp ]
77 °F
| [storage temp. ]
0-6°C
| [solubility ]
water: soluble0.2g/L | [form ]
Liquid | [pka]
>15 (Christensen et al., 1975) | [color ]
Colorless | [Odor]
Like benzene; characteristic aromatic. | [Relative polarity]
0.074 | [Stability:]
Stable. Incompatible with oxidizing agents. Hygroscopic. Flammable. | [explosive limit]
1.1-7%(V) | [Odor Threshold]
0.058ppm | [Water Solubility ]
Miscible with alcohol, ether, acetone, benzene and chloroform. Immiscible with water. | [λmax]
λ: 294 nm Amax: 1.00
λ: 320 nm Amax: 0.10
λ: 350 nm Amax: 0.05
λ: 380-400 nm Amax: 0.01 | [Merck ]
14,10081 | [BRN ]
1901563 | [Henry's Law Constant]
16.1 at 45.00 °C, 18.6 at 50.00 °C, 20.3 at 55.00 °C, 23.4 at 60.00 °C, 30.5 at 70.00 °C (static
headspace-GC, Park et al., 2004) | [Dielectric constant]
2.6（20℃） | [Exposure limits]
TLV-TWA100 ppm (～434 mg/m3) (ACGIH,
MSHA, and OSHA); STEL 150 ppm
(～651 mg/m3) (ACGIH); ceiling 200 ppm/
10 min (NIOSH); IDLH 1000 ppm (NIOSH). | [InChIKey]
URLKBWYHVLBVBO-UHFFFAOYSA-N | [LogP]
3.16 at 20℃ | [CAS DataBase Reference]
106-42-3(CAS DataBase Reference) | [EPA Substance Registry System]
p-Xylene (106-42-3) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T | [Risk Statements ]
R10:Flammable.
R20/21:Harmful by inhalation and in contact with skin .
R38:Irritating to the skin.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S25:Avoid contact with eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN 1307 3/PG 3
| [WGK Germany ]
2
| [RTECS ]
ZE2625000
| [Autoignition Temperature]
984 °F | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29024300 | [Safety Profile]
Moderately toxic by
intraperitoneal route. Mildly toxic by
ingestion and inhalation. An experimental
teratogen. Experimental reproductive
effects. May be narcotic in hgh
concentrations. Chronic toxicity not
established, but is less toxic than benzene. A
very dangerous fire hazard when exposed to
heat or flame; can react with oxidzing
materials. Explosive in the form of vapor
when exposed to heat or flame. To fight
fire, use foam, CO2, dry chemical.
Potentially explosive reaction with acetic
acid + air, 1,3-dichloro-5,5-dimethyl-2,4-
imidazolidinhone, nitric acid + pressure.
When heated to decomposition it emits
acrid smoke and irritating fumes. See also
other xylene entries. | [Hazardous Substances Data]
106-42-3(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 3910 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Sodium hydroxide-->Sulfuric acid-->Xylene-->m-Xylene-->COAL TAR-->Motor benzol-->light benzol-->Adsorbent | [Preparation Products]
m-Xylene-->1-Methylpiperazin-2-one-->o-Xylene-->Terephthalic acid-->Pigment Red 122-->p-Toluic acid-->Dimethyl terephthalate-->Pyromellitic Dianhydride-->2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester-->CHLORCYCLIZINE-->CHLORCYCLIZINE HYDROCHLORIDE-->Terephthaloyl chloride-->Terephthalaldehyde-->alpha,alpha'-Dibromo-p-xylene-->4-Bromomethylbenzoic acid-->p-Tolualdehyde-->1,4-BIS(TRICHLOROMETHYL)BENZENE-->CYCLOOCTANONE-->1,4-Dicyanobenzene-->1,4-Bis(aminomethyl)benzene-->METHYL 3-(THIEN-2-YL)ACRYLATE-->4-(Chloromethyl)benzoic acid-->Dacthal-->1,3-Bis(aminomethyl)benzene-->alpha,alpha'-Dichloro-p-xylene-->4-Methylbenzyl bromide-->1,4-Bis(methoxymethyl)benzene-->3,6-bis(bromomethyl)-1,2,4,5-tetrabromobenzene |
| Hazard Information | Back Directory | [General Description]
A colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. Freezing point is 56°F. | [Reactivity Profile]
P-XYLENE(106-42-3) may react with oxidizing materials. . Acetic acid forms explosive mixtures with P-XYLENE(106-42-3) and air (Shraer, B.I. 1970. Khim. Prom. 46(10):747-750.). | [Air & Water Reactions]
Highly flammable. Insoluble in water. | [Health Hazard]
Vapors cause headache and dizziness. Liquid irritates eyes and skin. If taken into lungs, causes severe coughing, distress, and rapidly developing pulmonary edema. If ingested, causes nausea, vomiting, cramps, headache, and coma. Can be fatal. Kidney and liver damage can occur. | [Fire Hazard]
Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. | [Chemical Properties]
colourless liquid | [Physical properties]
Clear, colorless, watery liquid with a sweet odor. Odor threshold concentrations reported in air
were 47 ppbv by Leonardos et al. (1969) and 58 ppbv by Nagata and Takeuchi (1990). | [Uses]
As solvent; raw material for production of benzoic acid, phthalic anhydride, isophthalic and terephthalic acids as well as their dimethyl esters used in the manufacture of polyester fibers; manufacture of dyes and other organics; sterilizing catgut; with Canada balsam as oil-immersion in microscopy; clearing agent in microscope technique. | [Uses]
p-Xylene is used as a precursor in the production of benzoic, isophthalic, tetraphillic acids and dimethyle esters, which are used in the manufacture of polyester. It acts as an intermediate in plastic and rubber products. | [Uses]
Xylene occurs in petroleum solvents andgasoline. The widest applications of xyleneare as solvents in paints, coatings, and rubber.Xylene isomers are used in the manufacture ofdyes, drugs, pesticides, and in many organicintermediates, such as terephthalic acid andphthalic anhydride. | [Definition]
ChEBI: A xylene with methyl groups at positions 1 and 4. | [Production Methods]
Pure p-xylene can be obtained from a mixture of o- and p-xylene by sulfonation and subsequent removal of water-soluble o-xylenesulfonic acid.
| [Synthesis Reference(s)]
The Journal of Organic Chemistry, 53, p. 3247, 1988 DOI: 10.1021/jo00249a020
Tetrahedron Letters, 26, p. 1935, 1985 DOI: 10.1016/S0040-4039(00)98345-X | [Flammability and Explosibility]
Flammable | [Chemical Reactivity]
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Source]
Detected in distilled water-soluble fractions No. 2 fuel oil (1.11 mg/L), jet fuel A (1.23
mg/L), diesel fuel (0.56 mg/L), and military jet fuel JP-4 (5.48 mg/L) (Potter, 1996); in new and
used motor oil at concentrations of 0.26 to 0.29 and 302 to 339 μg/L, respectively (Chen et al.,
1994). The average volume percent and estimated mole fraction in American Petroleum Institute
PS-6 gasoline are 1.809 and 0.02263, respectively (Poulsen et al., 1992). Diesel fuel obtained from
a service station in Schlieren, Switzerland contained m/p-xylene at a concentration of 336 mg/L
(Schluep et al., 2001).
Thomas and Delfino (1991) equilibrated contaminant-free groundwater collected from
Gainesville, FL with individual fractions of three individual petroleum products at 24–25 °C for
24 h. The aqueous phase was analyzed for organic compounds via U.S. EPA approved test method
602. Average m+p-xylene concentrations reported in water-soluble fractions of unleaded gasoline,
kerosene, and diesel fuel were 8.611, 0.658, and 0.228 mg/L, respectively. When the authors
analyzed the aqueous-phase via U.S. EPA approved test method 610, average m+p-xylene
concentrations in water-soluble fractions of unleaded gasoline, kerosene, and diesel fuel were
lower, i.e., 6.068, 0.360, and 0.222 mg/L, respectively.
Based on laboratory analysis of 7 coal tar samples, m+p-xylene concentrations ranged from ND
to 6,000 ppm (EPRI, 1990). Detected in 1-yr aged coal tar film and bulk coal tar at concentrations
of 260 and 830 mg/kg, respectively (Nelson et al., 1996). A high-temperature coal tar contained pxylene
at an average concentration of 0.03 wt % (McNeil, 1983).
Schauer et al. (2001) measured organic compound emission rates for volatile organic
compounds, gas-phase semi-volatile organic compounds, and particle-phase organic compounds
from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission
rate of m-xylene + p-xylene was 60.0 mg/kg of pine burned. Emission rates of both isomers were
not measured during the combustion of oak and eucalyptus.
Drinking water standard (final): For all xylenes, the MCLG and MCL are both 10 mg/L. In
addition, a DWEL of 70 mg/L was recommended (U.S. EPA, 2000). | [Environmental Fate]
Biological. Microbial degradation of p-xylene produced 4-methylbenzyl alcohol, pmethylbenzaldehyde,
p-toluic acid, and 4-methylcatechol (quoted, Verschueren, 1983). Dimethylcis,
cis-muconic acid, and 2,3-dihydroxy-p-toluic acid were reported to be biooxidation products of
p-xylene by Nocardia corallina V-49 using n-hexadecane as the substrate (Keck et al., 1989).
Reported biodegradation products of the commercial product containing xylene include
α-hydroxy-p-toluic acid, p-methylbenzyl alcohol, benzyl alcohol, 4-methylcatechol, m- and ptoluic
acids (Fishbein, 1985). It was reported that p-xylene was cometabolized resulting in the
formation of p-toluic and 2,3-dihydroxy-o-toluic acids (Pitter and Chudoba, 1990). In anoxic
groundwater near Bemidji, MI, p-xylene anaerobically biodegraded to the intermediate p-toluic
acid (Cozzarelli et al., 1990). In gasoline-contaminated groundwater, methylbenzylsuccinic acid
was identified as the first intermediate during the anaerobic degradation of xylenes (Reusser and
Field, 2002).
Photolytic. A n-hexane solution containing m-xylene and spread as a thin film (4 mm) on cold
water (10 °C) was irradiated by a mercury medium pressure lamp. In 3 h, 18.5% of the p-xylene
photooxidized into p-methylbenzaldehyde, p-benzyl alcohol, p-benzoic acid, and pmethylacetophenone
(Moza and Feicht, 1989). Glyoxal and methylglyoxal were produced from
the photooxidation of p-xylene by OH radicals in air at 25 °C (Tuazon et al., 1986a). The rate
constant for the reaction of p-xylene and OH radicals at room temperature was 1.22 x 10-11
cm3/molecule?sec (Hansen et al., 1975). A rate constant of 7.45 x 10-9 L/molecule?sec was reported
for the reaction of p-xylene with OH radicals in the gas phase (Darnall et al., 1976). Similarly, a
room temperature rate constant of 1.41 x 10-11 cm3/molecule?sec was reported for the vapor-phase
reaction of p-xylene with OH radicals (Atkinson, 1985). At 25 °C, a rate constant of 1.29 x 10-11
cm3/molecule?sec was reported for the same reaction (Ohta and Ohyama, 1985).
Chemical/Physical. Under atmospheric conditions, the gas-phase reaction with OH radicals and
nitrogen oxides resulted in the formation of p-tolualdehyde (Atkinson, 1990). Kanno et al. (1982)
studied the aqueous reaction of p-xylene and other aromatic hydrocarbons (benzene, toluene, oand
m-xylene, and naphthalene) with hypochlorous acid in the presence of ammonium ion. They
reported that the aromatic ring was not chlorinated as expected but was cleaved by chloramine
forming cyanogen chloride. The amount of cyanogen chloride formed increased at lower pHs
(Kanno et al., 1982). Products identified from the OH radical-initiated reaction of p-xylene in the
presence of nitrogen dioxide were 3-hexene-2,5-dione, p-tolualdehyde, and 2,5-dimethylphenol
(Bethel et al., 2000). | [Purification Methods]
The general purification methods listed for xylene above are applicable. p-Xylene can readily be separated from its isomers by crystallisation from such solvents as MeOH, EtOH, isopropanol, acetone, butanone, toluene, pentane or pentene. It can be further purified by fractional crystallisation by partial freezing, and stored over sodium wire or molecular sieves Linde type 4A. [Stokes & French J Chem Soc, Faraday Trans 1 76 537 1980, Beilstein 5 H 382, 5 I 185, 5 II 296, 5 III 845, 5 IV 951.] |
| Questions And Answer | Back Directory | [Description]
p-xylene is an aromatic hydrocarbon based on benzene with two methyl substituents with the chemical formula C8H10 or C6H4(CH3)2. It is one of the three isomers of dimethylbenzene known collectively as xylenes. The “p” stands for para, identifying that he two methyl groups in p-xylene occupy the diametrically opposite substituent positions 1 and 4. p-Xylene is a colorless, flammable liquid practically insoluble in water. p-Xylene is a colorless watery liquid with a sweet odor and is dangerously flammable, with a flash point of 27°C. p-Xylene is widely used as a feedstock (or “building block”) to manufacture other industrial chemicals, notably terephthalic acid (TPA), purified terephthalic acid (PTA) and dimethyl-terephthalate (DMT). It also may be polymerised directly to produce parylene.
| [References]
1.https://en.wikipedia.org/wiki/P-Xylene
2.https://pubchem.ncbi.nlm.nih.gov/compound/p-xylene#section=Top
3.https://www.chemicalsafetyfacts.org/paraxylene/
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