ChemicalBook--->CAS DataBase List--->109-73-9

109-73-9

109-73-9 Structure

109-73-9 Structure
IdentificationMore
[Name]

Butylamine
[CAS]

109-73-9
[Synonyms]

1-AMINOBUTANE
1-BUTANAMINE
1-BUTYLAMINE
AMINE C4
BA
BUTYLAMINE
FEMA 3130
MNBA
MONO-N-BUTYLAMINE
N-BUTYLAMINE
RARECHEM AL BW 0075
1-amino-1,1-dimethylethane
1-Amino-butaan
1-Aminobutan
1-Amino-butan
1-Butanaminen-butilamina
2-Amino-2-methylpropan
Aminobutane
Butanamine
Butylamin
[EINECS(EC#)]

203-699-2
[Molecular Formula]

C4H11N
[MDL Number]

MFCD00011690
[Molecular Weight]

73.14
[MOL File]

109-73-9.mol
Chemical PropertiesBack Directory
[Description]

n-Butylamine is one of the four isomeric amines of butane, the others being sec-butylamine, tert-butylamine, and isobutylamine. It is a colourless to yellow liquid and is highly flammable. It is stable and incompatible with oxidising agents, aluminium, copper, copper alloys, and acids. n-Butylamine finds its uses in the manufacture of pesticides (such as thiocarbazides), pharmaceuticals, and emulsifiers. It is also a precursor for the manufacture of N,N′-dibutylthiourea, a rubber vulcanisation accelerator, and n-butylbenzenesulphonamide, a plasticiser of nylon.
[Appearance]

Butyl amines are highly flammable, colorless liquids (n-turns yellow on standing) with ammoniacal or fishlike odors. n-isomer:
[Melting point ]

−49 °C(lit.)
[Boiling point ]

78 °C(lit.)
[density ]

0.74 g/mL at 25 °C(lit.)
[vapor density ]

2.5 (vs air)
[vapor pressure ]

68 mm Hg ( 20 °C)
[FEMA ]

3130
[refractive index ]

n20/D 1.401(lit.)
[Fp ]

30 °F
[storage temp. ]

2-8°C
[solubility ]

water: miscible
[form ]

Liquid
[pka]

10.77(at 20℃)
[color ]

Clear
[Odor]

Fish-like; ammonia-like.
[PH]

12.6 (100g/l, H2O, 20℃)
[Stability:]

Stable. Incompatible with oxidizing agents, aluminium, copper, copper alloys, acids. Highly flammable.
[explosive limit]

1.5-9.8%(V)
[Odor Threshold]

0.17ppm
[Odor Type]

ammoniacal
[Water Solubility ]

MISCIBLE
[Sensitive ]

Air Sensitive
[JECFA Number]

1582
[Merck ]

14,1543
[BRN ]

605269
[Henry's Law Constant]

1.76 (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
[Dielectric constant]

4.9(20℃)
[Exposure limits]

Ceiling 5 ppm (~15 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 2000 ppm (NIOSH).
[InChIKey]

HQABUPZFAYXKJW-UHFFFAOYSA-N
[LogP]

0 at 25℃
[CAS DataBase Reference]

109-73-9(CAS DataBase Reference)
[NIST Chemistry Reference]

1-Butanamine(109-73-9)
[EPA Substance Registry System]

109-73-9(EPA Substance)
Hazard InformationBack Directory
[Chemical Properties]

n-Butylamine is one of the four isomeric amines of butane, the others being sec-butylamine, tert-butylamine, and isobutylamine. It is a highly flammable, colorless to yellow liquid. It is stable and/but incompatible with oxidizing agents, aluminium, copper, copper alloys, and acids. n-Butylamine is used in the manufacture of pesticides (such as thiocarbazides), pharmaceuticals, and emulsifi ers. It is also a precursor for the manufacture of N,N’-dibutylthiourea, a rubber vulcanization accelerator, and n-butylbenzenesulfonamide, a plasticizer of nylon.
[General Description]

A clear colorless liquid with an ammonia-like odor. Flash point 10°F. Less dense (6.2 lb/gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.
[Reactivity Profile]

N-BUTYL AMINE reacts violently with strong oxidizing agents and acids. Attacks copper and copper compounds [Handling Chemicals Safely 1980 p. 123]. Reacts with hypochlorites to give N-chloroamines which may be explosive when isolated [Bretherick 1979 p. 108].
[Air & Water Reactions]

Highly flammable. Dissolves in water with evolution of heat. The resulting solutions are basic.
[Hazard]

Skin irritant. Flammable, dangerous fire risk. Eye and upper respiratory tract irritant.
[Health Hazard]

Exposures to butylamine (inhalation, ingestion, and through skin contact) are harmful. It is very destructive to the mucous membranes and causes, redness, severe deep burns, and loss of vision. Symptoms include, but are not limited to, sore throat, cough, burning sensation, headache, fl ushing of the face, vomiting, dizziness, abdominal pain, diarrhea, nausea, shock or collapse, shortness of breath, labored breathing, depression, convulsions, narcosis, and possibly unconsciousness. Exposure of this nature is unlikely, however, because of the irritating properties of the vapor. On catching fi re, butylamine gives off irritating or toxic fumes (or gases). Repeated or prolonged contact with the skin may cause dermatitis. The vapor is corrosive to the eyes, skin, and respiratory tract, and causes lung edema.
[Health Hazard]

Inhalation causes irritation, nausea, vomiting, headache, faintness, severe coughing and chest pains; can cause lung edema. Ingestion causes severe irritation of mouth and stomach. Contact with eyes causes severe irritation and edema of the cornea. Contact with skin causes burns; absorption through skin may cause nausea, vomiting and shock.
[Potential Exposure]

Alert: (n-isomer): Possible risk of forming tumors, suspected of causing genetic defects, suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (sec-isomer): Drug. n-Butylamine is used in pharmaceuticals; dyestuffs, rubber, chemicals, emulsifying agents; photography, desizing agents for textiles; pesticides, and synthetic agents. sec-Butylamine is used as a fungistate. tert-Butylamine is used as a chemical intermediate in the production of tert-Butylaminoethyl methacrylate (a lube oil additive); as an intermediate in the production of rubber and in rust preventatives and emulsion deterrents in petroleum products. It is used in the manufacture of several drugs
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Rinse out mouth and do not induce vomiting. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy
[Shipping]

UN1125 n-Butylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material. UN2014 Isobutylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material
[Incompatibilities]

May form explosive mixture with air. May accumulate static electrical charges, and may causeignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids, causing fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moisture. The tert-isomer will attack some forms of plastics
[Waste Disposal]

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner andscrubber. All federal, state, and local environmental regulations must be observed.
[Physical properties]

Butylamine has an ammoniacal odor (fishy, pungent). Clear, colorless liquid with a strong or pungent, ammonia-like odor. Slowly becomes pale yellow on prolonged storage. Experimentally determined detection and recognition odor threshold concentrations were 240 μg/m3 (80 ppbv) and 720 μmg/m3 (240 ppbv), respectively (Hellman and Small, 1974).

[Occurrence]

Reported found in mulberry leaves, kale, tomato, tilsit cheese, cheddar and other cheeses, caviar, fish, cooked chicken, cooked beef, beer, sherry and red wine.
[Uses]

Intermediate for pharmaceuticals, dyestuffs, rubber chemicals, emulsifying agents, insecticides, synthetic tanning agents.
[Uses]

Intermediate for pharmaceuticals, dyestuffs, rubber chemicals, emulsifying agents, insecticides, synthetic tanning agents
[Uses]

n-Butylamine is used as an intermediatefor various products, including dyestuffs,pharmaceuticals, rubber chemical, synthetictanning agents, and emulsifying agents. It isused for making isocyanates for coatings.
[Definition]

ChEBI: A primary aliphatic amine that is butane substituted by an amino group at position 1.
[Preparation]

Catalytic alkylation of ammonia with butyl alcohol.
[Production Methods]

n-Butylamine is usually manufactured by the catalytic alkylation of ammonia with butyl alcohol, or similarly from butyraldehyde and ammonia in the presence of Raney nickel. U.S. production in 1982 was approximately 1109 metric tons (SRI 1985). Some n-butylamine is also produced as a result of fertilizer manufacture, fish processing, rendering plant operations, and sewage treatment and has been reported to be a component of animal waste (Graedel 1978).
[Aroma threshold values]

Detection: 50 ppm
[Flammability and Explosibility]

Flammable
[Chemical Reactivity]

Reactivity with Water No reaction; Reactivity with Common Materials: May corrode some metals in presence of water; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
[Industrial uses]

n-Butylamine is an important intermediate in the production of pharmaceuticals, dyestuffs, synthetic tanning agents, insecticides, emulsifying agents, rubber accelerators, vulcanizing agents, and antioxidants (HSDB 1988). A flavor ingredient in seafood and chocolate, n-butylamine is also reported to be used in alcoholic beverages, ice cream, candy, baked goods, gelatins, and puddings all at a concentration of 0.1 p.p.m. (Fenaroli 1975). It is estimated that 50% of the n-butylamine produced is used for rubber processing chemicals and 50% as an intermediate in pesticide production (SRI 1982).
[Carcinogenicity]

The concentrated liquid produced severe eye damage and skin burns in animals.
[Environmental Fate]

Photolytic. Low et al. (1991) reported that the photooxidation of aqueous primary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. Reacts with mineral acids forming water-soluble salts.
At an influent concentration of 1.0 g/L, treatment with GAC resulted in effluent concentration of 480 mg/L. The adsorbability of the carbon used was 103 mg/g carbon (Guisti et al., 1974).
[Metabolism]

Considering the industrial importance of this amine, it is surprising that no thorough studies of its metabolism have been completed. Aliphatic amines, in general, are well-absorbed from the gut and respiratory tract and readily metabolised (Beard and Noe 1981; Magos and Manson 1983). After oral administration of n-butylamine hydrochloride to humans, little n-butylamine was recovered in the urine (Rechenberger 1940) suggesting that extensive metabolism occurs. Deamination of n-butylamine has been shown to occur in slices of rat liver and brain cortex (Pugh and Quastel 1937). It is assumed that monoamine oxidase plays a role in the detoxication process by catalyzing the deamination of n-butylamine to ammonia, hydrogen peroxide, and butyraldehyde. The ammonia produced is then converted to urea and the hydrogen peroxide is reduced by catalase. The aldehyde is probably converted to the corresponding carboxylic acid by aldehyde oxidase (Beard and Noe, 1981).
[Solubility in water]

Butylamine can dissolve in water by forming hydrogen bonds with water. Oxygen atoms in water hydrogen-bond to hydrogen atoms on the amine group.
[Purification Methods]

Dry it with solid KOH, K2CO3, LiAlH4, CaH2 or MgSO4, then reflux it with, and fractionally distil it from P2O5, CaH2, CaO or BaO. Further purification is by precipitation as the hydrochloride, m 213-213.5o, from ethereal solution by bubbling HCl gas into it. This is re-precipitated three times from EtOH by adding ether, followed by liberation of the free amine using excess strong base. The amine is extracted into ether, which is separated, dried with solid KOH, the ether removed by evaporation and then the amine is distilled. It is stored in a desiccator over solid NaOH [Bunnett & Davis J Am Chem Soc 82 665 1960, Lycan et al. Org Synth Coll Vol II 319 1943]. [Beilstein 4 IV 540.] SKIN IRRITANT.
Safety DataBack Directory
[Hazard Codes ]

F,C
[Risk Statements ]

R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R35:Causes severe burns.
[Safety Statements ]

S3:Keep in a cool place .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S29:Do not empty into drains .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 1125 3/PG 2
[WGK Germany ]

1
[RTECS ]

EO2975000
[F ]

34
[Autoignition Temperature]

594 °F
[TSCA ]

Yes
[HazardClass ]

3
[PackingGroup ]

II
[HS Code ]

29211980
[storage]

n-Butylamine should be protected against physical damage. Store in a cool, dry, wellventilated location, away from any area where the fi re hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfer to avoid static sparks.
[Safety Profile]

Poison by ingestion, skin contact, and intravenous routes. Moderately toxic by inhalation, intraperitoneal, and parenteral routes. A corrosive and severe skin irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A flammable liquid and dangerous fire hazard when exposed to heat, flame, or oxidzing materials. To fight fire, use alcohol foam, Con, dry chemical. Explodes on contact with perchloryl fluoride. When heated to decomposition it emits toxic fumes of NO,. See also AMINES.
[Hazardous Substances Data]

109-73-9(Hazardous Substances Data)
[Toxicity]

LD50 orally in rats: 500 mg/kg (Hine)
[IDLA]

300 ppm
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Sodium hydroxide-->Ammonium hydroxide-->Ammonia-->1-Butanol-->Water-->Aluminum oxide-->4-Chlorobenzaldehyde-->KAOLIN-->Dibutylamine-->1-Chlorobutane-->Molybdenum trioxide-->Tributylamine
[Preparation Products]

Bensulfuron methyl-->Chlorsulfuron-->Dibutylamine-->Butyl isocyanate-->Curcumin-->Tributylamine-->UV-photoxidation degradation film containing FeDBC photosensitize-->Simvastatin-->S-(-)-Carbidopa-->4-BUTYLAMINO-CHROMEN-2-ONE-->2-Fluorophenylacetone-->2-Methoxyphenylacetone-->Bupivacaine-->tert-Butylisocyanate-->Solvent Blue 35-->Methanimidamide, N,N'-dibutyl--->Transparent Blue-->1-Butanamine, N-(3-methyl-2(3H)-benzothiazolylidene)--->2-ANISIDINE-4-SULFOBUTYLAMIDE-->Solvent Blue 35
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

1-Butanamine(109-73-9).msds
Spectrum DetailBack Directory
[Spectrum Detail]

Butylamine(109-73-9)MS
Butylamine(109-73-9)1HNMR
Butylamine(109-73-9)13CNMR
Butylamine(109-73-9)IR1
Butylamine(109-73-9)IR2
Butylamine(109-73-9)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

n-Butylamine, 99.8%(109-73-9)
[Alfa Aesar]

1-Butylamine, 99%(109-73-9)
[Sigma Aldrich]

109-73-9(sigmaaldrich)
[TCI AMERICA]

Butylamine,>99.0%(GC)(109-73-9)
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