| Identification | Back Directory | [Name]
CH 55 | [CAS]
110368-33-7 | [Synonyms]
CH 55
4-[(E)-3-(3,5-Di-tert-butylphenyl)-3-oxo-1-propenyl]benzoic acid
4-[(E)-3-[3,5-Bis(tert-butyl)phenyl]-3-oxo-1-propenyl]benzoic acid
(E)-4-(3-(3,5-Bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)benzoic acid
4-[(E)-3-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid
4-[(1E)-3-[3,5-BIS(1,1-DIMETHYLETHYL)PHENYL]-3-OXO-1-PROPENYL]BENZOIC ACID
Benzoic acid, 4-(3-(3,5-bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)-, (E)-
Benzoic acid, 4-[(1E)-3-[3,5-bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propen-1-yl]- | [Molecular Formula]
C24H28O3 | [MDL Number]
MFCD06798383 | [MOL File]
110368-33-7.mol | [Molecular Weight]
364.48 |
| Chemical Properties | Back Directory | [Melting point ]
202-203.5 °C | [Boiling point ]
509.5±50.0 °C(Predicted) | [density ]
1.085±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
4.09±0.10(Predicted) | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
CH 55 is a synthetic analog of retinoic acid which is an effective inhibitor of angiogenesis. Retinoids and their analogs are also promising agents for cancer chemoprevention and therapy. | [Definition]
ChEBI: 4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid is a member of chalcones. | [Biological Activity]
Highly potent synthetic retinoid that has high affinity for RAR- α and RAR- β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC 50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC 50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM). | [storage]
Store at RT |
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| Company Name: |
BOC Sciences
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16314854226 |
| Website: |
www.bocsci.com |
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