| Identification | Back Directory | [Name]
Misoprostol Acid | [CAS]
112137-89-0 | [Synonyms]
MISOPROSTOL ACID
MISOPROSTOL FREE ACID
Misoprostol Acid USP/EP/BP
Misoprostol acid,racemic mixture
Misoprostol Acid, Technical Grade 65%
Misoprostol Acid (10 mg in 1 mL Methyl Acetate)
(-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E
(+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1
(+/-)-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E1
(11a,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic Acid
Misoprostol Acid, Technical Grade 65%
DISCONTINUED. See M368760
Prost-13-en-1-oic acid, 11,16-dihydroxy-16-methyl-9-oxo-, (11α,13E)-
Misoprostol free acid,(±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1 | [Molecular Formula]
C21H36O5 | [MDL Number]
MFCD07772001 | [MOL File]
112137-89-0.mol | [Molecular Weight]
368.51 |
| Chemical Properties | Back Directory | [Boiling point ]
538.3±50.0 °C(Predicted) | [density ]
1.118±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform | [form ]
Yellow viscous oil. | [pka]
4.77±0.10(Predicted) | [color ]
Pale Yellow | [Stability:]
Temperature Sensitive |
| Hazard Information | Back Directory | [Description]
Misoprostol is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid. | [Chemical Properties]
Pale Yellow Gel | [Uses]
A cytoprotective prostaglandin PGE1 analogue. | [Uses]
A metabolite of Misoprostol. Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration | [Uses]
Misoprostol Acid is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.
| [Biochem/physiol Actions]
Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue use to prevent non steroidal anti inflammatory drug-induced (NSAID) gastric ulcers; as a labor inducing and postpartum hemorrhage treatment agent. | [storage]
Store at -20°C |
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