| Identification | Back Directory | [Name]
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride | [CAS]
1177141-67-1 | [Synonyms]
CKI-7 dihydrochlorid
CKI-7 Dihydrochloride
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride | [Molecular Formula]
C11H14Cl3N3O2S | [MDL Number]
MFCD00897689 | [MOL File]
1177141-67-1.mol | [Molecular Weight]
358.672 |
| Chemical Properties | Back Directory | [Appearance]
Beige Solid | [Melting point ]
187-189°C | [storage temp. ]
-20°C Freezer | [solubility ]
H2O: >5mg/mL | [form ]
solid | [color ]
white to light tan |
| Hazard Information | Back Directory | [Chemical Properties]
Beige Solid | [Uses]
Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases | [Biochem/physiol Actions]
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM. | [storage]
Store at -20°C |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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